Dramatic and prolonged decrease of whole salivary secretion in nasopharyngeal carcinoma patients treated with radiotherapy

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Yee-Min JenDer-Min Wu

Abstract

This study evaluates: (1) the change in whole salivary secretion rates of nasopharyngeal carcinoma patients before, during, and after radiotherapy, especially during the first week of irradiation; (2) the recovery capability of salivary glands up to 2 years postirradiation; and (3) the possible prognostic factors affecting salivary gland functions. Fifty patients who completed conventional radiotherapy using either once-per-day or hyperfractionated technique were included. Both unstimulated and stimulated whole salivary flow rates and ratios (flow rate compared with baseline) were measured before, during, 1, 3, and 6 months, and 1 and 2 years after radiotherapy. Multivariate analysis of potential prognostic factors affecting the salivary secretion ratio was made. Salivary glands were very radiosensitive and responded to radiation very early. After 720 cGy at the fourth day of the 8-week treatment, the unstimulated and stimulated salivary flow rates had decreased by 40%-50%. The nadir was reached in many patients after 3600 cGy (4 weeks). A second phase of decrease in salivary secretion was noted after completion of radiotherapy. Different mechanisms may be responsible for salivary response after low and high dose of radiation. ...Continue Reading

References

Jun 1, 1977·Journal of Dental Research·I L ShannonW B Wescott
Jan 1, 1978·AJR. American Journal of Roentgenology·W B WescottJ I Thornby
Oct 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M D Leslie, S Dische
Oct 1, 1990·International Journal of Oral and Maxillofacial Surgery·Y Tomita, T Osaki
Dec 1, 1990·Oral Surgery, Oral Medicine, and Oral Pathology·R P LiuH J Keene
Jan 1, 1989·Archives of Oto-rhino-laryngology·L E Norberg, P G Lundquist
Oct 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·L C StephensL J Peters
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·G W Barendsen
Feb 1, 1983·International Journal of Radiation Oncology, Biology, Physics·H D ThamesG H Fletcher
Jun 1, 1982·International Journal of Radiation Oncology, Biology, Physics·K MossmanJ Chencharick
Jul 1, 1994·European Journal of Cancer. Part B, Oral Oncology·U FunegårdR Henriksson
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J S CooperS Silverman
Jan 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R E PriceL J Peters
Jan 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M D Leslie, S Dische
Jan 1, 1993·International Journal of Radiation Oncology, Biology, Physics·I H ValdezP C Fox
Aug 6, 2000·Japanese Journal of Pharmacology·Y Ishikawa, H Ishida
Mar 30, 2001·The Journal of Biological Chemistry·J E TowneA G Menon
Aug 16, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·M M Grisius
Dec 4, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·F R BurlageA Vissink
Jul 27, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Rob P CoppesAntonius W T Konings
Aug 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Yee-Min JenPei-Wei Shueng

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Citations

Feb 5, 2013·Cancer Chemotherapy and Pharmacology·Hiroyuki HaradaSatoru Shintani
Sep 20, 2008·Photomedicine and Laser Surgery·Luana CamposCarlos De Paula Eduardo
Oct 10, 2009·Photomedicine and Laser Surgery·Alyne SimõesJose Nicolau
Nov 26, 2009·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Alyne SimõesJosé Nicolau
Aug 1, 2015·Journal of Maxillofacial and Oral Surgery·R C LapiedraM D Turner
Sep 15, 2007·International Journal of Radiation Oncology, Biology, Physics·Mark S ChambersRobert Haddad
Sep 28, 2014·Clinical Oral Investigations·Christina P C SimDavid J Manton
May 10, 2011·Bone Marrow Transplantation·K Garming LegertG Dahllöf
Mar 20, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·S B JensenUNKNOWN Salivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cance
Aug 20, 2019·Journal of the National Cancer Institute. Monographs·Siri Beier JensenMary E Reyland

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