Dramatic increase of alpha-hydroxyaldehydes derived from plasmalogens in the aged human brain

Chemistry and Physics of Lipids
M WeisserG Spiteller

Abstract

Plasmalogens-substantial compounds of brain tissue--suffer degradation either by hydrolysis under production of aldehydes or by oxidation with lipid peroxylradicals by generation of plasmalogen epoxides. The latter react by addition of pentafluorobenzylhydroxylamine HCl (PFBHA HCL) under hydrolysis to alpha-hydroxyaldehydes which are immediately transformed to pentafluorobenzyloximes (PFBO). Likewise, free aldehydes are transformed to PFBO-derivatives. PFBO-derivatives of free aldehydes and PFBO-derivatives of alpha-hydroxyaldehydes were extracted and after trimethylsilylation quantified by GC/FID and by GC/MSD. The remaining aqueous phase, containing plasmalogens besides other lipids, was hydrolyzed by treatment with acid. The hydrolysis products of plasmalogens, long chain aldehydes, react with PFBHA HCl to produce PFBO-derivatives. These were also quantified by GC/FID. This method allows the quantification of plasmalogens, free aldehydes and plasmalogenepoxides in human brain samples to study changes in the relation of these compounds with increasing age. While the ratio of plasmalogens in respect to derived aldehydes seems to remain constant during life time, the quotient of plasmalogenepoxides to plasmalogens increases wit...Continue Reading

References

Jan 1, 1985·Experimental Neurology·J H HofteigC Keresztes-Nagy
Aug 15, 1984·Biochimica Et Biophysica Acta·T WatabeA Hiratsuka
Feb 11, 1982·Biochemical and Biophysical Research Communications·N ChacosJ Capdevila
Jun 19, 1995·Chemistry and Physics of Lipids·R Felde, G Spiteller
Dec 1, 1994·Chemistry and Physics of Lipids·F Paltauf
Jul 30, 1996·Chemistry and Physics of Lipids·A DuddaF Kobelt
Aug 19, 1996·Chemistry and Physics of Lipids·M Weisser, G Spiteller
Jul 1, 1956·Journal of Gerontology·D HARMAN
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

Mar 29, 2001·Chemistry and Physics of Lipids·A Möllenberg, G Spiteller
Apr 27, 2001·Mechanisms of Ageing and Development·G Spiteller
Aug 30, 2001·Experimental Gerontology·G Spiteller
Dec 6, 2007·Journal of Neurochemistry·Tobias HartmannMarcus O W Grimm
Jun 11, 2008·Journal of Neurochemistry·Mushfiquddin KhanInderjit Singh
Aug 14, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·A A Farooqui, L A Horrocks
Feb 1, 2005·Journal of Neural Transmission·M E GötzP Riederer
Oct 28, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Vijitha Senanayake, Dayan B Goodenowe
Aug 18, 2017·Acta Cardiologica·Alexander Nikolaevich Osipenko
Jun 3, 2018·The Journal of Biological Chemistry·Howard Goldfine
Jan 4, 2019·Chemical Research in Toxicology·Isaie SibomanaNicholas V Reo
Sep 25, 2009·Neurobiology of Aging·George Bartzokis

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