Dramatic response to temozolomide, irinotecan, and bevacizumab for recurrent medulloblastoma with widespread osseous metastases

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Phillip A BonneyJames D Battiste

Abstract

There is little evidence to guide the choice of chemotherapeutic agents for osseous metastases in medulloblastoma. Recently, triple therapy with temozolomide, irinotecan, and bevacizumab has been reported to have efficacy in recurrent medulloblastoma, and this regimen alone and in combination with other agents has been tested in several early-phase clinical trials. Here we report a 20-year-old woman with multiply-relapsed medulloblastoma with numerous osseous metastases 8 years after original diagnosis who responded dramatically to temozolomide, irinotecan, and bevacizumab therapy. This case highlights the potential for this regimen in treating osseous metastases in medulloblastoma.

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Citations

Mar 7, 2017·Clinical Nuclear Medicine·Abhishek MahajanRakesh Jalali
Jul 18, 2019·American Journal of Clinical Oncology·Mackenzie CummingsNicholas G Zaorsky
Apr 26, 2018·Neuro-oncology Practice·Karen GauvainJonathan McConathy
Mar 25, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Amalia SchiavettiClaudio Di Biasi
Jan 21, 2021·Molecular Oncology·Shavali ShaikVidya Gopalakrishnan
Oct 5, 2021·Expert Opinion on Therapeutic Targets·Shavali ShaikVidya Gopalakrishnan

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