Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1

Cell Metabolism
Andrei I Tarasov, Patrik Rorsman

Abstract

How is β-cell mass adjusted to changes in the functional insulin requirements? The answer to this question is central to the understanding of the causes and (potentially) the therapy of type 2 diabetes. In this issue of Cell Metabolism, El Ouaamari et al. (2016) report that increased production of the protease inhibitor SerpinB1 in the liver links insulin resistance to stimulation of β-cell proliferation.

References

Mar 20, 2012·Cell·Frances M Ashcroft, Patrik Rorsman
Nov 25, 2014·Cell·Viktoria GusarovaJesper Gromada
Dec 25, 2015·Cell Metabolism·Abdelfattah El OuaamariRohit N Kulkarni

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Citations

Mar 24, 2016·International Journal of Molecular Sciences·Stefano BallestriAmedeo Lonardo
May 18, 2021·Biochemistry and Biophysics Reports·Masayoshi IshidaHiroshi Kaji

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