Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling.

Nature
Jennifer S ZiegenfussMarc R Freeman

Abstract

The cellular machinery promoting phagocytosis of corpses of apoptotic cells is well conserved from worms to mammals. An important component is the Caenorhabditis elegans engulfment receptor CED-1 (ref. 1) and its Drosophila orthologue, Draper. The CED-1/Draper signalling pathway is also essential for the phagocytosis of other types of 'modified self' including necrotic cells, developmentally pruned axons and dendrites, and axons undergoing Wallerian degeneration. Here we show that Drosophila Shark, a non-receptor tyrosine kinase similar to mammalian Syk and Zap-70, binds Draper through an immunoreceptor tyrosine-based activation motif (ITAM) in the Draper intracellular domain. We show that Shark activity is essential for Draper-mediated signalling events in vivo, including the recruitment of glial membranes to severed axons and the phagocytosis of axonal debris and neuronal cell corpses by glia. We also show that the Src family kinase (SFK) Src42A can markedly increase Draper phosphorylation and is essential for glial phagocytic activity. We propose that ligand-dependent Draper receptor activation initiates the Src42A-dependent tyrosine phosphorylation of Draper, the association of Shark and the activation of the Draper pathway...Continue Reading

References

Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·A W FerranteE R Stanley
May 1, 1996·Genes & Development·M N LioubinL R Rohrschneider
May 29, 1998·Progress in Neurobiology·H Aldskogius, E N Kozlova
Oct 3, 2001·The Journal of Clinical Investigation·V A FadokP M Henson
Oct 10, 2001·Current Biology : CB·P M HensonV A Fadok
Dec 4, 2002·Nature Reviews. Immunology·John SavillChris Haslett
Oct 14, 2003·Trends in Immunology·Lisa A Pitcher, Nicolai S C van Oers
Apr 16, 2004·Current Biology : CB·Ryan J WattsLiqun Luo
Mar 31, 2005·Trends in Immunology·Giorgio BertonClifford A Lowell
Sep 6, 2005·Current Biology : CB·Africa CoutoBarry J Dickson
Dec 8, 2005·Immunology Letters·Szabina FodorAttila Mócsai
Dec 13, 2005·Development·Romi BiswasE Richard Stanley
Mar 25, 2006·Nature Reviews. Immunology·John G Monroe
Sep 19, 2006·Nature Neuroscience·Darren W WilliamsJames W Truman
Jan 2, 2007·Trends in Immunology·David M Underhill, Helen S Goodridge

❮ Previous
Next ❯

Citations

Sep 19, 2009·Seminars in Immunopathology·Lisa Walter, Harald Neumann
Feb 15, 2012·Cell and Tissue Research·Bettina LinnartzHarald Neumann
Mar 18, 2009·Apoptosis : an International Journal on Programmed Cell Death·John F FullardNicholas E Baker
May 13, 2010·Apoptosis : an International Journal on Programmed Cell Death·Jason M Kinchen
Aug 13, 2013·Cell Death and Differentiation·C D Gregory
Aug 2, 2011·Nature Cell Biology·Zhenjie LuJonathan Kipnis
Jun 19, 2012·Nature Neuroscience·Jennifer S ZiegenfussMarc R Freeman
May 15, 2010·Nature Reviews. Immunology·Attila MócsaiVictor L J Tybulewicz
Sep 2, 2010·The Journal of Experimental Medicine·Kodi S Ravichandran
Jan 7, 2009·Journal of Biochemistry·Yumi Tohyama, Hirohei Yamamura
Jun 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suneil HosmaneArun Venkatesan
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kenneth J Colodner, Mel B Feany
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Johnna DohertyMarc R Freeman
Sep 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jami L ScheibBruce D Carter
Aug 20, 2010·International Journal of Alzheimer's Disease·Bettina LinnartzHarald Neumann
Mar 13, 2014·ILAR Journal·Timothy M Rooney, Marc R Freeman
Apr 20, 2014·Molecular Biology of the Cell·Chelsea S SullivanBruce D Carter
Jul 22, 2014·Mediators of Inflammation·Young-Su YiJae Youl Cho
May 17, 2014·Glycobiology·Bettina Linnartz-GerlachHarald Neumann
Aug 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tsai-Yi LuMarc R Freeman
Jul 27, 2012·Annual Review of Cell and Developmental Biology·Yanshan Fang, Nancy M Bonini
Dec 24, 2013·Genes & Development·Ozge E Tasdemir-Yilmaz, Marc R Freeman
Feb 5, 2013·Cellular and Molecular Life Sciences : CMLS·Buvana Ravishankar, Tracy L McGaha
Aug 28, 2015·Journal of Neurogenetics·Yuan-Ming Lee, Y Henry Sun
Jan 28, 2009·The Journal of Cell Biology·Elsa-Noah N'DiayeWilliam E Seaman
Aug 12, 2009·The Journal of Cell Biology·Marc Freeman
Feb 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Allison K TimmonsKimberly McCall
Apr 14, 2015·Nature Communications·Margaret M P PearceRon R Kopito
Feb 7, 2017·Nature Communications·Tsai-Yi LuMarc R Freeman
Sep 16, 2008·Cellular Signalling·Vassilis J Marmaras, Maria Lampropoulou
Sep 24, 2009·Nature Reviews. Neuroscience·Christian Klämbt
Aug 12, 2014·The American Journal of Pathology·Isabelle DraperPeter B Kang
Jul 22, 2014·Developmental Biology·Boris ShklyarEstee Kurant
May 27, 2014·Seminars in Immunology·Brian M Stramer, Marc S Dionne
May 13, 2017·Human Molecular Genetics·Madhurima SahaPeter B Kang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.