Dravet syndrome and deep brain stimulation: seizure control after 10 years of treatment

Epilepsia
Danielle M AndradeRichard A Wennberg

Abstract

Dravet syndrome is a genetically determined severe epilepsy associated with cognitive decline and ataxia. The many types of seizures seen in these patients are typically pharmacoresistant. Here we describe two adults with Dravet syndrome who were treated with thalamic deep brain stimulation (DBS) and followed for 10 years. One patient with partial onset seizures received DBS at age 19 and showed a marked improvement in seizure control after DBS insertion and stimulation. The other patient with generalized onset seizures received DBS at age 34 and did not show any immediate benefit. No side effects or changes in cognition were observed in either of the patients. This is the first report of (short- and) long-term results in Dravet patients treated with thalamic DBS. We speculate that the results of DBS for epilepsy in patients with Dravet syndrome may be related to age at initiation of DBS treatment and seizure type.

References

May 19, 2001·American Journal of Human Genetics·L ClaesP De Jonghe
Jun 13, 2002·Epilepsia·Mojgan HodaieAndres M Lozano

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Citations

May 5, 2012·Epilepsia·Berten CeulemansLieven Lagae
Jul 12, 2012·Epilepsia·Jennifer J RilstoneDanielle M Andrade
Nov 30, 2013·Epilepsy Research and Treatment·J FridleyS Agadi
Oct 26, 2010·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Nelia ZamponiCristina Petrelli
Nov 30, 2015·Clinical Neurology and Neurosurgery·Neil V Klinger, Sandeep Mittal
Mar 12, 2016·Paediatric Drugs·Adam WallaceDaniel L Kenney-Jung
Dec 9, 2017·Epilepsia·Michael C H Li, Mark J Cook
Mar 29, 2018·Epilepsia Open·Yicong Lin, Yuping Wang
May 5, 2011·Expert Review of Neurotherapeutics·Mike R SchoenbergSelim R Benbadis
Jul 1, 2011·Neurosurgery·Faisal A Al-OtaibiAndres M Lozano
Jun 28, 2019·Frontiers in Neurology·Nasser ZangiabadiJosé Francisco Téllez-Zenteno
Oct 17, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Manuel L HerreraJorge G Burneo

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