DRB1*03:01 haplotypes: differential contribution to multiple sclerosis risk and specific association with the presence of intrathecal IgM bands.

PloS One
Emilio G de la ConchaConcepción Núñez

Abstract

Multiple sclerosis (MS) is a multifactorial disease with a genetic basis. The strongest associations with the disease lie in the Human Leukocyte Antigen (HLA) region. However, except for the DRB1*15:01 allele, the main risk factor associated to MS so far, no consistent effect has been described for any other variant. One example is HLA-DRB1*03:01, with a heterogeneous effect across populations and studies. We postulate that those discrepancies could be due to differences in the diverse haplotypes bearing that allele. Thus, we aimed at studying the association of DRB1*03:01 with MS susceptibility considering this allele globally and stratified by haplotypes. We also evaluated the association with the presence of oligoclonal IgM bands against myelin lipids (OCMB) in cerebrospinal fluid. Genotyping of HLA-B, -DRB1 and -DQA1 was performed in 1068 MS patients and 624 ethnically matched healthy controls. One hundred and thirty-nine MS patients were classified according to the presence (M+, 58 patients)/absence (M-, 81 patients) of OCMB. Comparisons between groups (MS patients vs. controls and M+ vs. M-) were performed with the chi-square test or the Fisher exact test. Association of DRB1*03:01 with MS susceptibility was observed but ...Continue Reading

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Citations

Oct 18, 2015·Human Immunology·Zohreh Tatari-CalderoneRyad Tamouza
May 29, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Hugo GonzálezRodrigo Pacheco
Dec 3, 2016·Expert Review of Molecular Diagnostics·Matteo GastaldiDiego Franciotta
Oct 12, 2018·Current Medicinal Chemistry·Kustrimovic NatasaMarco Cosentino
Mar 5, 2019·Frontiers in Immunology·Javier Campos-AcuñaRodrigo Pacheco

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Methods Mentioned

BETA
genotyping

Software Mentioned

Review Manager ( RevMan )
Arlequin
EpiInfo

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