Drd2 expression in the high alcohol-preferring and low alcohol-preferring mice.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Paula J BiceLucinda G Carr

Abstract

The high alcohol-preferring (HAP) and low alcohol-preferring (LAP) mice were selectively bred for differences in alcohol preference and consumption. Recently, a large-effect QTL was identified on chromosome 9. The peak for this QTL is near the Drd2 (dopamine receptor 2) locus. The present study examined Drd2 mRNA expression differences between the HAP1 and LAP1 mice in brain regions important in the dopaminergic-reward pathway, including the nucleus accumbens, hippocampus, amygdala, and septum. Results show that alcohol-naïve HAP1 mice exhibited lower levels of Drd2 mRNA expression in the nucleus accumbens and the hippocampus compared to LAP1 mice. No differences were found in the amygdala or septum. To determine if a sequence difference might underlie the expression difference, the Drd2 cDNA was sequenced in each line and one single nucleotide polymorphism (SNP) was identified in the 3' UTR. Both HAP and LAP 3' UTR were cloned in the luc-pGL3-promoter-luc vector. The polymorphism in the Drd2 3' UTR was assessed to determine its functional significance in modulating expression. In vitro expression analysis using neuroblastoma SK-N-SH cells resulted in a significant decrease in expression of the HAP 3' UTR luc construct compared...Continue Reading

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Citations

Apr 6, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·So Hee LeeIhn Geun Choi
May 30, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Brandon M Fritz, Stephen L Boehm
Oct 21, 2010·Alcoholism, Clinical and Experimental Research·Panayotis K ThanosNora D Volkow
Apr 28, 2012·Journal of Forensic Sciences·Muradiye NacakSukru Aynacioglu
Nov 19, 2013·Behavioural Brain Research·Todd M DarlingtonMarissa A Ehringer
Jan 13, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eduardo F GalloChristoph Kellendonk
Nov 19, 2013·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Nao HagiwaraTerrance L Albrecht

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