DRD3 gene and striatum in autism spectrum disorder

The British Journal of Psychiatry : the Journal of Mental Science
Wouter G StaalSarah Durston

Abstract

A single-nucleotide polymorphism (SNP) of the DRD3 gene (rs167771) was recently associated with autism spectrum disorders (ASD). Different polymorphisms of rs167771 corresponded to varying degrees of stereotyped behaviour. As DRD3 receptors are relatively overexpressed in the striatum, we investigated whether striatal volume was related to these polymorphisms in autism. We assessed volumes of caudate nucleus and putamen in 86 participants with ASD (mean age 15.3 years). MANCOVA showed an association between alleles of the rs167771 SNP and the volume of striatal structures. Furthermore, greater caudate nucleus volume correlated with stereotyped behaviour. These findings support a relationship between DRD3 gene SNPs, striatum and stereotyped behaviour in ASD.

References

Dec 9, 2008·Biological Psychiatry·Mariken de KromJan M van Ree
May 9, 2009·Biological Psychiatry·Marieke LangenSarah Durston
Jun 10, 2009·The Pharmacogenomics Journal·P GassóA Lafuente
Feb 16, 2010·Neuroscience and Biobehavioral Reviews·Marieke LangenWouter G Staal
Jun 22, 2011·Journal of Autism and Developmental Disorders·Wouter G StaalMaretha V de Jonge
Mar 9, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Claudio TomaBru Cormand
Dec 21, 2012·Expert Review of Neurotherapeutics·Holly L RedpathJeremy Hall
Oct 5, 2013·Biological Psychiatry·Marieke LangenSarah Durston

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Citations

Jun 15, 2017·The European Journal of Neuroscience·Julieta AcostaPatricia V Agostino
Nov 2, 2019·Journal of Autism and Developmental Disorders·M A L Mostert-KerckhoffsW G Staal
Mar 19, 2020·Brain Sciences·Rosa MarottaMichele Roccella
Dec 14, 2018·Frontiers in Cellular Neuroscience·Hsiao-Ying Kuo, Fu-Chin Liu
Sep 10, 2020·Journal of Neurochemistry·Luis A- Trujillo VillarrealAlberto Camacho-Morales
Jul 17, 2021·Frontiers in Molecular Neuroscience·Elzbieta ZieminskaJerzy W Lazarewicz
Aug 10, 2021·Frontiers in Neural Circuits·Polina Kosillo, Helen S Bateup
Sep 3, 2021·Brain and Behavior·Miguel Comparan-MezaAlma Y Galvez-Contreras
Oct 30, 2021·Frontiers in Neural Circuits·K Ushna S IslamSandra Blaess

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