DRD4 and SLC6A3 gene polymorphisms are associated with food intake and nutritional status in children in early stages of development

The Journal of Nutritional Biochemistry
Crisciele FontanaSilvana Almeida

Abstract

Variants of dopamine system genes such as the DRD4 and the SLC6A3 genes may be involved in food intake regulation because the dopaminergic system influences food reward. We investigated an association of polymorphisms in the DRD4 (exon 3 VNTR) and SLC6A3 (3'UTR VNTR, rs2550948, rs2652511 and rs1048953) genes with food intake and nutritional status in children. This prospective cohort study recruited 359 children at birth. Dietary data and nutritional status were collected at 1 year, 3-4 years, and 7-8 years of age. The polymorphisms were analyzed using polymerase chain reaction based techniques. Food intake and nutritional status were compared among the different SNP genotypes. In the first year of life, DRD4.7R- children showed higher BMI Z-scores (P=.019) than the DRD4.7R+ cohort. At 3-4 years old, DRD4.7R- and SLC6A3.10R/10R children showed a higher intake of palatable foods (P=.024) and a higher waist circumference (P=.017). The rs1048953 SLC6A3 polymorphism was associated with average daily energy intake (P=.003) at 3-4 years and with a waist-to-height ratio of children at 7-8 years (P=.041). Carriers of high dopamine activity alleles of the VNTRs studied in DRD4 and SLC6A3 genes and carriers of T/T genotype of the variant...Continue Reading

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Citations

Nov 18, 2017·Archives of Physiology and Biochemistry·Yeimy González-GiraldoDiego A Forero
Nov 7, 2016·Journal of Attention Disorders·Tomasz HanćAgnieszka Słopień
Jul 13, 2018·Brain and Behavior·Omar Ramos-LopezUNKNOWN MENA Project
May 24, 2017·World Journal of Gastroenterology : WJG·Arturo PanduroSonia Roman

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