Abstract
As access to antiretroviral treatment increases in the developing countries, efforts towards making it easier and less costly to collect, store, and deliver the biological samples to reference laboratories, where the serological and genetic diagnosis techniques are performed, have become a high priority. Blood sampling on filter papers is an inexpensive and practical alternative to plasma for antiretroviral treatment monitoring in countries with limited resources and no access to cold chains or refrigeration. The main clinical applications and uses of blood-sampling onto filter papers (dried blood spots [DBS]) are reviewed, focusing on how these can be applied in monitoring HIV infection, particularly for use in National Health Programs in developing countries, or in resource-limited settings. A review is presented of studies that have used the DBS technique for quantifying viral load, analysis of antiretroviral drug-resistance mutations, early infant diagnosis, adult serological diagnosis, detection of viral p24 antigen, and molecular epidemiology of HIV-1, in different geographical locations. Those variables that could affect the use of DBS, particularly in the HIV field, as well as explaining how these procedures can be opti...Continue Reading
References
Mar 1, 1987·Human Genetics·E R McCabeM L Law
May 8, 2003·Journal of Clinical Microbiology·Don BrambillaSusan A Fiscus
May 26, 2005·Journal of Virological Methods·Sumonmal UttayamakulRuengpung Sutthent
Jun 14, 2005·Archives of Medical Research·Ma Tereza Alvarez-MuñozOnofre Muñoz
Apr 22, 2006·Clinical Chemistry·Christian DrostenWolfgang Preiser
Oct 13, 2006·PLoS Medicine·Susan A FiscusUNKNOWN Forum for Collaborative HIV Research Alternative Viral Load Assay Working Group
Dec 15, 2006·Journal of Clinical Microbiology·Amanda McNultyJ Gerardo García-Lerma
Dec 30, 2006·PLoS Medicine·Wolfgang PreiserChristian Drosten
Aug 3, 2007·Journal of Clinical Microbiology·Kim SteegenChris Verhofstede
Aug 10, 2007·Journal of Virological Methods·Kim SteegenMarleen Temmerman
Nov 21, 2007·AIDS·Silvina MasciotraJ Gerardo García-Lerma
Dec 14, 2007·Journal of Clinical Microbiology·Qi ZhangYujiang Jia
Jan 15, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Laura WatersMark Nelson
Feb 5, 2008·Journal of Virological Methods·Coumba Toure KaneSouleymane Mboup
Feb 5, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Renee HallackMonica M Parker
Sep 13, 2008·Expert Review of Molecular Diagnostics·François RouetEric Nerrienet
Oct 28, 2008·Journal of Virological Methods·W LeelawiwatJ M McNicholl
Nov 4, 2008·Current Opinion in Infectious Diseases·Andrew J Buckton
Dec 17, 2008·Journal of Clinical Microbiology·Ada CachafeiroSusan A Fiscus
Feb 6, 2009·Journal of Clinical Microbiology·Marjorie MonleauMartine Peeters
Feb 12, 2009·Journal of Medical Microbiology·Vemu LakshmiLalit Dandona
Feb 18, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A MarconiM Zazzi
Jun 9, 2009·PloS One·Nishaki MehtaMohan Somasundaran
Jun 16, 2009·Journal of Virological Methods·S ReigadasH J Fleury
Jul 22, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·André Dieudonné MbidaThomas Bourlet
Aug 7, 2009·Journal of Clinical Microbiology·Wendy LabbettAnna Maria Geretti
Aug 12, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Asgeir JohannessenCarmen de Mendoza
Aug 29, 2009·PloS One·Sumathi SivapalasingamFred Valentine
Sep 11, 2009·AIDS·Sarah M LofgrenJohn A Crump
Dec 8, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mauro AndreottiMarina Giuliano
May 12, 2010·Journal of Viral Hepatitis·V D HopeJ V Parry
May 25, 2010·Archives of Virology·Rosalia LiraMa-Teresa Alvarez-Muñoz
Jun 15, 2010·The Journal of Antimicrobial Chemotherapy·Marjorie MonleauMartine Peeters
Dec 1, 2010·The Journal of Antimicrobial Chemotherapy·Asgeir JohannessenCarmen de Mendoza
Citations
Jun 7, 2013·Clinical and Vaccine Immunology : CVI·Africa HolguínJosé A Pérez-Molina
Aug 6, 2013·Sexually Transmitted Infections·Faran EmmanuelTahira Ezra Reza
Jan 21, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Carolina Fernández McPheeAfrica Holguín
Jun 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·José Naranjo, Ottorino Cosivi
Oct 27, 2016·Pediatric Research·Patricia AlvarezÁfrica Holguín
Apr 7, 2019·Scientific Reports·Marina Rubio-GarridoÁfrica Holguín
Oct 30, 2020·Scientific Reports·Marina Rubio-GarridoÁfrica Holguín
Jul 3, 2021·Frontiers in Medicine·Marina Rubio-GarridoÁfrica Holguín
Aug 23, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·David BarquínGabriel Reina