PMID: 6408466Feb 1, 1983Paper

Drift in ultraviolet sensitivity and expression of mutations during synchronous growth of cyanobacterium Anacystis nidulans

Mutation Research
D V Amla

Abstract

Synchrony with respect to cell division and DNA synthesis in cultures of Anacystis nidulans was induced by a light-dark-light regimen. At periodic intervals in the cell-division cycle, DNA, RNA, protein contents, UV sensitivity and induction of mutations were assayed. The DNA, RNA and protein syntheses were periodic and reached maximal values before the separation of cells. The DNA content started to increase at about the 5th hour and doubled at about the 13th hour followed by a plateau of 4-6 h. Wild-type A. nidulans was highly sensitive to UV radiation during the period showing an increase in cell number (rise phase) and the early part of DNA synthesis (synthetic phase). Significant resistance to UV, however, developed in the later stage of the DNA synthesis. This resistance decreased considerably during the next rise phase. On the other hand, in a UV-sensitive strain of A. nidulans (uvs67) there was no appreciable change in the UV sensitivity during the cell-division and DNA-synthesis phases. Induction of mutation frequency patterns of all the markers (fil, blu, yel, vir, nit, strR) in the wild-type showed a short initial lag followed by an abrupt increase resulting in a peak of mutation frequency in the early part of DNA sy...Continue Reading

References

Jun 1, 1975·Journal of General Microbiology·S F Delaney, N G Carr
Jan 1, 1978·Journal of Bacteriology·D R ZusmanM Cumsky
Apr 15, 1976·Journal of Molecular Biology·C E Helmstetter, O Pierucci
Jan 1, 1969·Annual Review of Microbiology·E M Witkin
Jan 1, 1970·Molecular & General Genetics : MGG·S V Shestakov, N T Khyen
Feb 1, 1968·Photochemistry and Photobiology·H Werbin, C S Rupert
Jul 1, 1956·Journal of Bacteriology·H D BARNER, S S COHEN

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