Drinking and changes in blood pressure in response to precursors, fragments and analogues of angiotensin II in the pigeon Columba livia

The Journal of Physiology
M D Evered, J T Fitzsimons

Abstract

1. The pigeon drank as vigorously in response to intracranial injection of synthetic renin substrate and angiotensin I as to angiotensin II. 2. Mammalian renin injected into the brain caused the water-replete pigeon to drink but it was a less effective dipsogen than in the mammal. As in the mammal, renin-induced drinking was slower in onset and continued for longer than angiotensin-induced drinking. 3. The converting enzyme inhibitor SQ 20881 attenuated drinking in response to intracranial renin, synthetic renin substrate and angiotensin I but enhanced intracranial angiotensin II-induced drinking. Therefore drinking induced by the intracranial injection of precursors of angiotensin II is mediated through local generation of angiotensin II. 4. I.V. injection of angiotensin I was as effective as angiotensin II in causing the pigeon to drink, but synthetic renin substrate was less effective. I.V. doses of angiotensin I and II had to be about 100 times greater than the intracranial doses in order to produce similar intakes. 5. Angiotensin I and II were equally effective pressor agents by I.V. injection in the pigeon but synthetic renin substrate was much less effective. I.V. SQ 20881 inhibited the pressor response to I.V. synthetic...Continue Reading

Citations

Jan 1, 1996·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·E Simon, H A Schmid
Jun 1, 1992·General and Comparative Endocrinology·B UvaP Ghiani
Mar 12, 1984·Brain Research·J W WrightJ W Harding
Oct 9, 2016·Anatomical Science International·Hiroko Nishimura
Jan 1, 1989·Journal of Endocrinological Investigation·G Ramieri, G C Panzica
Jul 23, 1998·Physiological Reviews·J T Fitzsimons
Mar 30, 1993·European Journal of Pharmacology·S Y OseiP J Kadowitz

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