Drinking patterns in genetic low-alcohol-drinking (LAD) rats after systemic cyanamide and cerebral injections of THP or 6-OHDA

Alcohol
M W WestR D Myers

Abstract

A key question related to the role of acetaldehyde and aldehyde adducts in alcoholism concerns their relationship to the genetic mechanisms underlying drinking. Experimentally, the low-alcohol-drinking (LAD) rat represents a standard rodent model having a strong aversion to alcohol. In these experiments, preferences for water vs. alcohol, offered in concentrations from 3% to 30%, were determined over 10 days in adult LAD rats (N = 6 per group). Then a saline vehicle or either 10 or 20 mg/kg of the aldehyde dehydrogenase (AIDH) inhibitor, cyanamide, was injected s.c. twice daily for 3 days. Secondly, either 0.5 or 1.0 microg of tetrahydropapaveroline (THP) was infused i.c.v. twice daily for 3 days in LAD rats (N = 8) and, as a genetic control, THP also was infused identically in Sprague-Dawley (SD) rats (N = 8). The results showed that the lower and higher doses of cyanamide augmented alcohol intakes in 33% and 50% of the LAD rats, respectively, with the patterns of drinking resembling that of genetic high-alcohol-drinking HAD or P rats. Although i.c.v. infusions of THP had little effect on alcohol preference of LAD rats, alcohol drinking was enhanced significantly in the SD rats. In a supplementary study, 200 microg of 6-hydrox...Continue Reading

References

Apr 1, 1992·Pharmacogenetics·D P Agarwal, H W Goedde
May 1, 1992·Trends in Pharmacological Sciences·G F Koob
Oct 1, 1991·Alcoholism, Clinical and Experimental Research·L G CarrT K Li
Jun 1, 1991·British Journal of Addiction·P BuckleyC Larkin
Mar 1, 1985·Alcoholism, Clinical and Experimental Research·D K RexT K Li
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Mar 1, 1985·Alcohol·S M SocaranskyZ Amit
Jun 1, 1984·Japanese Journal of Pharmacology·H KuribaraS Tadokoro
Jun 1, 1982·Pharmacology, Biochemistry, and Behavior·R D MyersW D Ruwe
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·K IwahashiY Ichikawa
Feb 1, 1994·Pharmacology, Biochemistry, and Behavior·C FahlkeE Hård
Oct 1, 1995·Alcoholism, Clinical and Experimental Research·S M Zimatkin, R A Deitrich
Nov 1, 1995·Alcohol·M E Quintanilla, L Tampier
Feb 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F TanakaM Omata
Feb 1, 1996·Alcoholism, Clinical and Experimental Research·K GillR A Deitrich

❮ Previous
Next ❯

Citations

Jun 8, 2001·Alcoholism, Clinical and Experimental Research·C J Eriksson
Apr 18, 2003·Metabolism: Clinical and Experimental·A B BonnerV R Preedy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.