PMID: 11606168Oct 19, 2001Paper

Drinking water composition and childhood-onset Type 1 diabetes mellitus in Devon and Cornwall, England

Diabetic Medicine : a Journal of the British Diabetic Association
H X ZhaoB A Millward

Abstract

Previous studies have reported inconsistent results on the association between some compositions (e.g. nitrate) in domestic water and the risk of childhood-onset Type 1 diabetes mellitus. This study aimed to examine the relationship between nitrate, zinc and magnesium in drinking water and the risk of childhood-onset Type 1 diabetes mellitus. The study covers the Cornwall and the former Plymouth Health Authority Regions in the far south-west of England. Five hundred and seventeen children, aged 0-15 years, diagnosed with Type 1 diabetes mellitus between 1975 and 1996, were identified for inclusion in the study. Domestic water data (nitrate, Zn, Mg, Cu, Al, Ca, Fe and Mn) between 1993 and 1997 were provided by South-west Water Plc, UK, for each of the 40 Water Supply Zones in which the subjects had been resident at the time of diagnosis. The standardized incidence ratio (SIR) of the disease was calculated for each Water Supply Zone using the UK 1991 census population data. The relationship between the SIR of the disease and the water quality indicators in thirds (three strata of low, medium and high concentrations) was examined by chi2 test for trend and Poisson regression analysis. The initial analyses by chi2 test for trend on...Continue Reading

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Citations

May 8, 2002·Diabetes/metabolism Research and Reviews
Jul 16, 2010·Human Genetics·Jana Kralovicova, Igor Vorechovsky
Feb 7, 2013·Frontiers of Medicine·Xiao MiaoLu Cai
Jul 31, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·H X ZhaoB A Millward
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Feb 13, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·H X ZhaoB A Millward
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