Drivers of Hospital Readmission and Early Liver Transplant after Kasai Portoenterostomy.

The Journal of Surgical Research
Emily L RyonChad M Thorson

Abstract

Kasai portoenterostomy (KPE) remains the first-line operation for patients with biliary atresia (BA), but ultimately fails in up to 60% of cases. This study sought to identify factors contributing to hospital readmission and early liver transplant. The Nationwide Readmissions Database from 2010 to 2014 was used to identify patients with BA who underwent KPE on index admission. Patient factors, hospital characteristics, and complications of BA were compared by readmission rates and rate of liver transplant within 1 y. The results were weighted for national estimates. Nine hundred and sixty three patients were identified. The readmission rate within 30-d was 36% (n = 346) and within 1-y was 67% (n = 647). Only 9% (n = 90) received a liver transplant within a year. The most common complications after KPE were cholangitis in 58%, decompensated cirrhosis in 54%, and recurrent jaundice in 34%. Male patients (OR 1.5, P = 0.02) with comorbid gastrointestinal anomalies (OR 2.1, P < 0.01) from lower income households (OR 4.6, P < 0.01) and early development of cirrhosis (OR 3.0, P < 0.01) were more likely to be readmitted. Liver transplant was more common in men (OR 4.0, P < 0.01) and those from lower income households (OR 5.2, P < 0.01)...Continue Reading

References

Oct 1, 1990·Journal of Pediatric Surgery·F M KarrerR J Hall
Mar 1, 1997·Pediatrics·P W YoonM J Khoury
Apr 5, 2003·Journal of Pediatric Surgery·Ling-Nan BuMei-Hwei Chang
Jul 29, 2006·Orphanet Journal of Rare Diseases·Christophe Chardot
Aug 17, 2010·Surgery·Mehul V RavalRiccardo Superina
Nov 16, 2011·The Journal of Pediatrics·Willemien de VriesUNKNOWN Netherlands Study Group of Biliary Atresia and Registry (NeSBAR)
Jan 1, 2014·Journal of Paediatrics and Child Health·Jie Ying LeeMarion Aw
May 27, 2015·Nature Reviews. Gastroenterology & Hepatology·Akihiro AsaiJorge A Bezerra
Jan 5, 2016·The Journal of Pediatrics·Benjamin L ShneiderUNKNOWN Childhood Liver Disease Research Network (ChiLDReN)
Jun 28, 2016·Journal of Autoimmunity·Bhanumathi Lakshminarayanan, Mark Davenport
Sep 22, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shikha S SundaramRonald J Sokol
Jul 27, 2017·The Journal of Pediatrics·Perri C HopkinsCade M Nylund
Jun 20, 2018·Pediatric Surgery International·Alejandro V GarciaDaniel S Rhee
Mar 19, 2019·Journal of Pediatric Surgery·Gabriel Ramos-GonzalezHeung Bae Kim
Jan 25, 2020·Journal of Pediatric Gastroenterology and Nutrition·Seung Hwan BaekJong Gyun Ahn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.