Driving forces for the mutual conversions between phenothiazines and their various reaction intermediates in acetonitrile

The Journal of Physical Chemistry. B
Xiao-Qing ZhuJin-Pei Cheng

Abstract

The thermodynamic driving forces (defined as the enthalpy changes or redox potentials in this work) of the 18 phenothiazines and their analogues, phenoxazine, N-methyl-dihydrophenazine, 9H-thioxanthene, 9H-xanthene and 9,10-dihydro- N-methylacridine, to release hydride, hydrogen atom, proton, and electron in acetonitrile, the thermodynamic driving forces of the radical cations of the phenothiazines and the analogues to release hydrogen atom, proton, and electron in acetonitrile, and the thermodynamic driving forces of the cations of the phenothiazines with two positive charges and their analogues to release proton in acetonitrile were estimated by using experimental methods. The effect of the remote substituents on the 11 determined thermodynamic driving forces were examined according to Brown's substituent parameters; the results show that the values of the 11 thermodynamic driving forces all are linearly dependent on the sum of Brown substituent parameters (sigma +) with very good correlation coefficients, which indicates that for any one- or multisubstituted at para- and/or meta-position phenothiazines and their various reaction intermediates, the 11 thermodynamic driving forces all can be easily and safely estimated from th...Continue Reading

References

Sep 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·J R White, H H Dearman
Jan 31, 1972·Biochemical and Biophysical Research Communications·M NishikimiK Yagi
Jun 1, 1972·Analytical Chemistry·V R White, J M Fitzgerald
Aug 1, 1972·Photochemistry and Photobiology·R NilssonD R Kearns
Mar 1, 1969·Journal of Medicinal Chemistry·T N TozerJ C Craig
Mar 1, 1994·Neurochemical Research·M CiniA Moretti
Oct 28, 1998·Free Radical Research·A Dalla LiberaA Bindoli
May 16, 1997·The Journal of Organic Chemistry·Philip A. MacFaulK. U. Ingold
Aug 9, 2002·Journal of the American Chemical Society·Jacques LalevéeJean-Pierre Fouassier
Sep 13, 2002·Journal of the American Chemical Society·Derek A PrattK U Ingold
Oct 2, 2003·Chemical Communications : Chem Comm·Soo-Keun Lee, Andrew Mills
Apr 24, 2004·The Journal of Organic Chemistry·Yong FengQing-Xiang Guo
Aug 5, 2004·Journal of the American Chemical Society·Emily A WeissMichael R Wasielewski
Nov 24, 2004·Luminescence : the Journal of Biological and Chemical Luminescence·V HadjimitovaY Baba
Dec 22, 2004·The Journal of Biological Chemistry·Sayuri TaniguchiMasato Hasegawa
Jul 13, 2005·The Journal of Biological Chemistry·Kuntebommanahalli N ThimmaiahPeter J Houghton
Jun 1, 2006·Bioorganic & Medicinal Chemistry·Andrzej B HendrichKrystyna Michalak
Jun 6, 2006·Biochemical and Biophysical Research Communications·Attila KónyaIstván Kurucz
Jun 15, 2006·The Journal of Physical Chemistry. B·Dae Won ChoTetsuro Majima
Jun 28, 2006·The Journal of Physical Chemistry. B·Tiago RodriguesIseli L Nantes
Sep 21, 2006·Chemistry & Biology·Moriz MayerThomas L James

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Citations

Dec 8, 2011·Journal of Chemical Information and Modeling·Jing ShiYao Fu
Jul 6, 2010·Chemical Communications : Chem Comm·N S Saleesh KumarJames N Wilson
Aug 16, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Yan HaoAnders Hagfeldt
Mar 16, 2018·Chemical Society Reviews·Stefan IlicKsenija D Glusac
Apr 22, 2011·Chemistry : a European Journal·Karl Martin KarlssonLicheng Sun
Nov 30, 2018·Nanoscale Research Letters·Khushboo SharmaS S Sharma
Jan 28, 2012·Chemical Society Reviews·Chao Zheng, Shu-Li You
Apr 17, 2020·Chemistry : a European Journal·Elmira GhabraieNorbert Sewald
Jun 12, 2020·European Journal of Medicinal Chemistry·Maria Giulia NiziOriana Tabarrini
Oct 1, 2020·Inorganic Chemistry·Jaruwan AmtawongT Don Tilley

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