Droloxifene prevents ovariectomy-induced bone loss in tibiae and femora of aged female rats: a dual-energy X-ray absorptiometric and histomorphometric study

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
H K ChenD D Thompson

Abstract

Our previous studies indicated that droloxifene (DRO), a tissue-specific estrogen antagonist/agonist, prevented bone loss without causing uterine hypertrophy in growing ovariectomized (OVX) rats. Using dual-energy X-ray absorptiometry (DXA) and bone histomorphometry, the current study compared the efficacy of DRO to 17 beta-estradiol (E2) in preventing OVX-induced bone loss in tibiae and femora of 19-month-old rats to determine whether DRO had similar skeletal effects as E2 in aged female rats. Sprague-Dawley female rats were OVX or sham-operated (sham) at 19 months of age. The sham-operated rats were treated with vehicle (oral), while the OVX rats were treated with vehicle (oral), E2 at 30 micrograms/kg/day (sc), or DRO at 2.5, 5, or 10 mg/kg/day (oral) for 8 weeks. Bone mineral density (BMD) of whole femora (WF), distal femoral metaphyses (DFM), femoral shafts (FS), and proximal femora (PF) was determined using DXA. Static and dynamic cancellous bone histomorphometric analyses were performed in double-labeled undecalcified longitudinal sections from proximal tibial metaphyses. Ovariectomy for 8 weeks significantly reduced the BMD of WF, DFM, FS, and PF (from -6 to -15%). Treatment with E2 completely prevented the decreases in...Continue Reading

References

Sep 1, 1992·Bone and Mineral·H M Frost, W S Jee
Feb 1, 1992·Calcified Tissue International·S LikimaniM E Kunkel
Dec 5, 1991·The American Journal of Medicine·C C Johnston, C W Slemenda
Dec 1, 1991·Bone and Mineral·D N Kalu
Jan 1, 1991·American Journal of Clinical Oncology·U EppenbergerW Küng
Jan 1, 1990·Annals of the New York Academy of Sciences·R Lindsay, F Cosman
Dec 1, 1989·Calcified Tissue International·T J WronskiM Cintrón
Jan 1, 1989·Endocrinology·D N KaluB W Hollis
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
May 1, 1987·American Journal of Obstetrics and Gynecology·M I Whitehead, D Fraser
Jan 1, 1969·Calcified Tissue Research·H M Frost
Jan 1, 1983·Metabolic Bone Disease & Related Research·J M Mbuyi-MuambaA Burssens
Jan 1, 1980·Calcified Tissue International·D B Kimmel, W S Jee
Nov 20, 1980·The New England Journal of Medicine·N S WeissJ R Daling
Nov 1, 1994·Endocrinology·C H TurnerH U Bryant
May 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M SatoC W Slemenda
Jun 1, 1994·Endocrine Reviews·R T TurnerT C Spelsberg
Mar 30, 1994·Biochemical and Biophysical Research Communications·S H JeeT J Chen
Sep 1, 1993·Calcified Tissue International·T J WronskiC F Yen

❮ Previous
Next ❯

Citations

Mar 17, 1999·American Journal of Obstetrics and Gynecology·C P SpencerJ M Rymer
May 30, 2001·Molecular and Cellular Endocrinology·R J BollagC M Isales
Feb 7, 2001·Trends in Endocrinology and Metabolism : TEM·L V Avioli
Oct 1, 1996·Annals of the Rheumatic Diseases·S Patel
Apr 1, 2002·Journal of the American Aging Association·H Z KeD D Thompson
May 1, 1997·Journal of Cellular Biochemistry·W A GrasserV M Paralkar
Jul 21, 1998·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·B D Golden
Jan 1, 1996·Investigative Radiology·S J GrierM R Alvis
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P ChavassieuxP J Meunier
Nov 23, 2006·Arquivos brasileiros de endocrinologia e metabologia·Adolfo Diez-Perez
Jan 1, 1997·The American Journal of the Medical Sciences·J Y Reginster

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.