Drooling in Parkinson's Disease: Prevalence and Progression from the Non-motor International Longitudinal Study.

Dysphagia
Daniel J van WamelenK Ray Chaudhuri

Abstract

Sialorrhoea in Parkinson's disease (PD) is an often neglected yet key non-motor symptom with impact on patient quality of life. However, previous studies have shown a broad range of prevalence figures. To assess prevalence of drooling in PD and its relationship to quality of life, we performed a retrospective analysis of 728 consecutive PD patients who had a baseline and follow-up assessment as part of the Non-motor International Longitudinal Study (NILS), and for whom drooling presence and severity were available, assessed through the Non-Motor Symptoms Scale (NMSS). In addition, we analysed the prevalence of associated dysphagia through self-reported outcomes. Quality of life was assessed through the PDQ-8 scale. Baseline (disease duration 5.6 years) prevalence of drooling was 37.2% (score ≥ 1 NMSS question 19), and after 3.27 ± 1.74 years follow-up, this was 40.1% (p = 0.17). The prevalence of drooling increased with age (p < 0.001). The severity of drooling, however, did not change (p = 0.12). While in 456 patients without drooling at baseline, only 16% (n = 73) had dysphagia (question 20 of the NMSS), in those with drooling this was 34.3% (p < 0.001). At follow-up, the number of patients with dysphagia had increased, 20.4%...Continue Reading

References

May 1, 1967·Neurology·M M Hoehn, M D Yahr
Jul 1, 1983·Archives of General Psychiatry·M F FolsteinJ E Helzer
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Jul 13, 2000·Acta Neurologica Scandinavica·B ScottS M Aquilonius
Nov 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·K R ChaudhuriC Trenkwalder
Feb 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·J MarinusJ J van Hilten
Mar 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Pablo Martínez-MartínIvana Zamarbide
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Melisa ProulxMichel Panisset
Dec 20, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Jean-Paul MeningaudJacques-Charles Bertrand
Jan 19, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Omar R TumilasciJorge H Pazo
Jun 5, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Pablo Martinez-MartinK Ray Chaudhuri
Aug 3, 2007·Journal of Neurology·Johanna G KalfMarten Munneke
Aug 4, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Kallol Ray ChaudhuriAnthony H V Schapira
Sep 15, 2007·Parkinsonism & Related Disorders·Denise Hack NicarettaMilton Melciades Barbosa Costa
Nov 30, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Cindy ZadikoffConnie Marras
Jan 13, 2010·Parkinsonism & Related Disorders·Joshua LeibnerHubert H Fernandez
Jan 30, 2010·Parkinsonism & Related Disorders·M A van der MarckB R Bloem
May 4, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·K Ray ChaudhuriPablo Martinez-Martin
Jul 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Marios PolitisPaola Piccini
Apr 2, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S Perez-LloretUNKNOWN COPARK Study Group
Apr 13, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Johanna G KalfMachiel J Zwarts
Jan 17, 2013·Journal of Clinical Neurology·Seong-Beom KohJong Sam Baik
May 10, 2013·Arquivos De Gastroenterologia·Denise Hack NicarettaMilton M B Costa
May 29, 2013·European Neurology·Abdul Qayyum RanaMurat Emre
Jan 1, 2011·Journal of Parkinson's Disease·Maria G CersosimoEduardo E Benarroch
Sep 10, 2014·Parkinsonism & Related Disorders·Prachaya SrivanitchapoomMark Hallett
Dec 30, 2014·Parkinsonism & Related Disorders·Ruwei OuHuifang Shang
Feb 17, 2015·Parkinson's Disease·Yair ZlotnikTanya Gurevich
Apr 22, 2015·Journal of the Neurological Sciences·Ruwei OuHuifang Shang
Oct 19, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R ErroP Barone
May 27, 2017·Brain : a Journal of Neurology·Seyed-Mohammad FereshtehnejadRonald B Postuma
Nov 28, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J C NienstedtC Pflug
May 23, 2018·Dysphagia·Hannah ReynoldsRichard Walker

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Citations

Aug 14, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ronald F Pfeiffer
Aug 2, 2020·Nature Reviews. Gastroenterology & Hepatology·R Alberto TravagliMichael Camilleri
Sep 4, 2020·Journal of Neural Transmission·Olivier RascolUNKNOWN COPARK Study Group
Nov 29, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Kathryn A Chung, Ronald F Pfeiffer
Nov 29, 2020·Parkinsonism & Related Disorders·Nicki NiemannJoseph Jankovic
Jan 15, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·David Nascimento
Feb 2, 2021·Expert Review of Neurotherapeutics·Katarina RukavinaK Ray Chaudhuri
Jul 13, 2021·Journal of Parkinson's Disease·Manon AuffretMarc Vérin
Jul 29, 2021·Journal of Movement Disorders·Yue Hui LauNorlinah Mohamed Ibrahim

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