PMID: 9549647Apr 29, 1998Paper

Droperidol elimination after cardiopulmonary bypass surgery

Journal of Clinical Pharmacology
C A SawyerF Regaglia

Abstract

A high-dose (0.75 to 2.8 mg/kg) pharmacokinetic study of droperidol was undertaken in patients during the recovery phase after cardiac surgery involving hypothermic cardiopulmonary bypass (CPB). The elimination half-life of droperidol in these patients, determined from concentration-time data obtained after CPB, was significantly prolonged relative to previously reported mean values in younger surgical patients not undergoing CPB and receiving lower doses of the drug (0.05-0.20 mg/kg). On stratification of the patients by droperidol dose, there was an inverse correlation between the size of the dose and the elimination half-life of droperidol: mean half-life decreased as mean dose increased. This difference in elimination half-life was not related to the duration of the CPB procedure, or the total anesthetic time, both of which were not significantly different between the patient groups receiving the three different doses of droperidol. The magnitude or duration of hypothermia after CPB did not differ between the three patient groups. The differences in half-lives are more likely due to the clinical condition of the patients, such that the patients who received the higher doses of droperidol were also judged clinically to be le...Continue Reading

References

Sep 1, 1977·Clinical Pharmacokinetics·M M Ghoneim, K Korttila
Mar 1, 1991·Biopharmaceutics & Drug Disposition·B P ImbimboE Imbimbo
Sep 1, 1988·British Journal of Anaesthesia·K A LehmannJ Heykants
Apr 1, 1986·Anesthesiology·M FischlerG Vourc'h
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Aug 1, 1980·British Journal of Anaesthesia·J G Bovill, P S Sebel
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Citations

Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·Martin CzernyMartin Grabenwoger
Aug 18, 2016·British Journal of Clinical Pharmacology·Lee-Kien FooGeoffrey K Isbister

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