Droperidol-ondansetron combination versus droperidol alone for postoperative control of emesis after total abdominal hysterectomy

Journal of Clinical Anesthesia
T J RileyD L Hamilton

Abstract

To investigate the hypothesis that the combination of ondansetron and droperidol would be more effective than droperidol alone in reducing nausea and vomiting. Randomized, doubleblind study. Magee-Womens Hospital, Pittsburgh, Pennsylvania. 160 healthy, ASA physical status I and II, female patients scheduled for total abdominal hysterectomy. After induction of anesthesia with propofol, Group 1 received intravenous (i.v.) droperidol 1.25 mg plus i.v. ondansetron 4 mg. Group 2 received i.v. droperidol plus i.v. saline. The complete response (no emesis, no rescue) for Group 1 was 36 of 80 patients (45%) versus 30 of 80 patients (38%) in Group 2 (p = 0.21). In Group 1, 42 of 80 patients (53%) required rescue antiemetic as compared with 44 of 80 patients (55%) in Group 2 (p = 0.43). There were 72 total rescues in Group 1 versus 73 in Group 2, (p = 0.24). Mean time until first rescue was 578 +/- 429 minutes in Group 1 and 418 +/- 354 minutes in Group 2, (p = 0.03). In Group 1, 81 % (34/42) were rescued for nausea only versus 90% (39/44) of Group 2 (p = 0.16). In Group 1, 21% of patients (17/80) had at least one emetic episode versus 34% (27/80) of Group 2 patients (p = 0.05). There were 31 emetic episodes in Group 1 versus 72 episodes...Continue Reading

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Citations

Dec 13, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W Scott Beattie
Jun 30, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·O WuG Koutsoukos
Jun 1, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W P McKay, R W Yip
Dec 22, 2011·British Journal of Anaesthesia·A Chandrakantan, P S A Glass
Feb 22, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Ninnie Borendal WodlinUNKNOWN 'GASPI' Study Group
Apr 2, 2003·Expert Opinion on Pharmacotherapy·Ashraf S Habib, Tong J Gan
Oct 24, 2003·International Anesthesiology Clinics·Ashraf S Habib, Tong J Gan
Dec 10, 1999·Anesthesia and Analgesia·P F White, M F Watcha
Jul 18, 2017·The Cochrane Database of Systematic Reviews·John Carlisle, Carl A Stevenson
Oct 20, 2020·The Cochrane Database of Systematic Reviews·Stephanie WeibelPeter Kranke

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