Droperidol/ondansetron combination controls nausea and vomiting after tubal banding

Anesthesia and Analgesia
R McKenzieD L Hamilton

Abstract

The antiemetic activity of droperidol is attributed to antagonizing the dopaminergic neurons of the chemoreceptor trigger zone. Ondansetron is a serotonin (5HT) receptor antagonist at both peripheral and central 5-HT3 receptor sites with no known action on dopamine-mediated activity. We hypothesized that the combination of these two antiemetics would be more effective than droperidol alone. Women with ASA classified physical status I or II, scheduled for laparoscopic tubal banding, participated in a randomized double-blind clinical trial using a standardized anesthesia regimen. Within 15 min after induction of anesthesia, Group 1 (n = 60) received IV droperidol 1.25 mg and ondansetron 4 mg and Group 2 (n = 60) received IV droperidol 1.25 mg and saline. Before surgery and during recovery at 1, 2, and 24 h, emetic episodes, nausea, pain, drowsiness, medications taken, and adverse events were recorded. The complete response (no emesis, no rescue) for Group 1 was 55 of 60 (91.6%) versus 47 of 60 (78.3%) in Group 2 (P = 0.04). No patient needed rescue antiemetic medication in Group 1, whereas 5 of 60 (8.3%) patients were rescued in Group 2 (P = 0.03). There were seven emetic episodes in five patients in Group 1 and 30 emetic episode...Continue Reading

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Citations

Jul 21, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y FujiiH Toyooka
Dec 13, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W Scott Beattie
Jun 30, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·O WuG Koutsoukos
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Jun 19, 2003·Anesthesiology Clinics of North America·David Cameron, Tong Joo Gan
Jun 19, 2003·Anesthesiology Clinics of North America·Brid McGrath, Frances Chung
Oct 24, 2003·International Anesthesiology Clinics·Phillip E Scuderi
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Oct 5, 2006·Current Opinion in Anaesthesiology·Anne Marie Troy, Anthony J Cunningham
Oct 3, 2006·Current Opinion in Anaesthesiology·R Y Fragneto

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