Droplet Breakup in Expansion-contraction Microchannels

Scientific Reports
Pingan ZhuLiqiu Wang

Abstract

We investigate the influences of expansion-contraction microchannels on droplet breakup in capillary microfluidic devices. With variations in channel dimension, local shear stresses at the injection nozzle and focusing orifice vary, significantly impacting flow behavior including droplet breakup locations and breakup modes. We observe transition of droplet breakup location from focusing orifice to injection nozzle, and three distinct types of recently-reported tip-multi-breaking modes. By balancing local shear stresses and interfacial tension effects, we determine the critical condition for breakup location transition, and characterize the tip-multi-breaking mode quantitatively. In addition, we identify the mechanism responsible for the periodic oscillation of inner fluid tip in tip-multi-breaking mode. Our results offer fundamental understanding of two-phase flow behaviors in expansion-contraction microstructures, and would benefit droplet generation, manipulation and design of microfluidic devices.

References

May 1, 2001·Physical Review Letters·T ThorsenS R Quake
Apr 17, 2003·Journal of Biotechnology·Michihiko NakanoAkira Mizuno
Mar 6, 2004·Physical Review Letters·D R LinkH A Stone
Mar 7, 2006·Nature Reviews. Drug Discovery·Petra S Dittrich, Andreas Manz
Jul 28, 2006·Nature·George M Whitesides
Nov 7, 2006·Angewandte Chemie·Helen SongRustem F Ismagilov
Oct 13, 2007·Physical Review Letters·Pierre GuillotArmand Ajdari
Apr 2, 2008·International Journal of Cosmetic Science·V B Patravale, S D Mandawgade
May 8, 2009·Chemical Society Reviews·Mary Ann Augustin, Yacine Hemar
Jun 18, 2009·Lab on a Chip·Heather M EvansThomas Pfohl
Jun 19, 2010·Lab on a Chip·Charles N BaroudRémi Dangla
Jul 14, 2012·Reports on Progress in Physics·Ralf SeemannStephan Herminghaus
Apr 24, 2013·Journal of the American Chemical Society·Alireza AbbaspourradDavid A Weitz
Apr 30, 2013·Journal of Physics D: Applied Physics·J K NunesH A Stone
Oct 23, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Ju Hyeon KimSeung-Man Yang
Nov 10, 2013·Accounts of Chemical Research·Wei WangLiang-Yin Chu
Mar 15, 2014·Soft Matter·Tiantian KongHo Cheung Shum
Oct 14, 2014·International Journal of Pharmaceutics·Ikram Ullah KhanThierry F Vandamme
Apr 24, 2015·Scientific Reports·Khashayar KhoshmaneshKourosh Kalantar-zadeh
Jun 17, 2015·Scientific Reports·Pingan ZhuLiqiu Wang

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Citations

Aug 12, 2016·Scientific Reports·Pingan ZhuLiqiu Wang
Oct 24, 2017·Nature Communications·Ye TianLiqiu Wang
Jul 11, 2020·Reports on Progress in Physics·J M Montanero, A M Gañán-Calvo
Nov 15, 2016·Lab on a Chip·Pingan Zhu, Liqiu Wang
Mar 21, 2019·Electrophoresis·Huanhuan FengJinhong Guo
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daiki TanakaShuichi Shoji
Jun 25, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Xing HanLiqiu Wang
Dec 18, 2021·Chemical Reviews·Pingan Zhu, Liqiu Wang

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