Apr 30, 2020

Evaluation of the potassium channel tracer 3F4AP in rhesus macaques

BioRxiv : the Preprint Server for Biology
N. GuehlPedro Brugarolas

Abstract

Demyelination causes slowed or failed neuronal conduction and is a driver of disability in multiple sclerosis and other neurological diseases. Currently, the gold standard for imaging demyelination is MRI, but despite its high spatial resolution and sensitivity to demyelinated lesions, it remains challenging to obtain specific and quantitative measures of demyelination. To understand the contribution of demyelination in different diseases and to assess the efficacy of myelin-repair therapies, it is critical to develop new in vivo imaging tools sensitive to changes induced by demyelination. Upon demyelination, axonal K+ channels, normally located underneath the myelin sheath, become exposed and increase in expression, causing impaired conduction. Here, we investigate the properties of the K+ channel PET tracer [18F]3F4AP in primates and its sensitivity to a focal brain injury that occurred three years prior to imaging. [18F]3F4AP exhibited favorable properties for brain imaging including high brain penetration, high metabolic stability, high plasma availability, high reproducibility, high specificity, and fast kinetics. [18F]3F4AP showed preferential binding in areas of low myelin content as well as in the previously injured are...Continue Reading

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Mentioned in this Paper

Laboratory Procedures
Genes
MPZ gene
Bulk (Conceptual)
Silo (Dataset)
Multiple Myeloma
Laboratory mice
Reverse Transcription
Cell Cluster
Research Study

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