Drosophila Bicoid is a substrate of sumoylation and its activator function is subject to inhibition by this post-translational modification.

FEBS Letters
Junbo Liu, Jun Ma

Abstract

Bicoid (Bcd) is a Drosophila morphogenetic protein and a transcriptional activator. Genetic studies have suggested a role of sumoylation in Bcd function, but it is unknown how Bcd activity is affected specifically by its own sumoylation status. Here we show that Bcd is sumoylated in Drosophila cells. We identify a lysine residue of Bcd as the primary sumoylation site. Using a Bcd mutant defective in being sumoylated, we show that sumoylation of Bcd is inhibitory to its ability to activate transcription. We provide evidence suggesting that the SUMO moiety has an intrinsic inhibitory activity for the activator function of Bcd.

References

Jul 1, 1988·Cell·W Driever, C Nüsslein-Volhard
Oct 1, 1969·Journal of Theoretical Biology·L Wolpert
Jan 5, 2002·Molecular and Cellular Biology·Vinay BhaskarAlbert J Courey
Jan 28, 2004·Cell·Anne Ephrussi, Daniel St Johnston
Jun 11, 2004·Annual Review of Biochemistry·Erica S Johnson
Apr 6, 2005·Molecular Cell·Ronald T Hay
Dec 22, 2005·Nature Reviews. Genetics·Alfonso Martinez Arias, Penelope Hayward
Jun 7, 2006·Annual Review of Cell and Developmental Biology·Oliver KerscherMark Hochstrasser
Jan 27, 2007·Cell·Arthur D Lander
Jul 31, 2007·Cell·Michel Kerszberg, Lewis Wolpert
Nov 15, 2007·Nature Reviews. Molecular Cell Biology·Ruth Geiss-Friedlander, Frauke Melchior
Oct 16, 2009·Epigenetics : Official Journal of the DNA Methylation Society·Jian Ouyang, Grace Gill
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Ortrud WartlickMarcos González-Gaitán
Aug 12, 2010·Development·Oliver Grimm, Eric Wieschaus
Nov 26, 2010·Nature Reviews. Molecular Cell Biology·Jaclyn R Gareau, Christopher D Lima

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