PMID: 9548723May 23, 1998Paper

Drosophila centrosomin protein is required for male meiosis and assembly of the flagellar axoneme

The Journal of Cell Biology
K LiT C Kaufman

Abstract

Centrosomes and microtubules play crucial roles during cell division and differentiation. Spermatogenesis is a useful system for studying centrosomal function since it involves both mitosis and meiosis, and also transformation of the centriole into the sperm basal body. Centrosomin is a protein localized to the mitotic centrosomes in Drosophila melanogaster. We have found a novel isoform of centrosomin expressed during spermatogenesis. Additionally, an anticentrosomin antibody labels both the mitotic and meiotic centrosomes as well as the basal body. Mutational analysis shows that centrosomin is required for spindle organization during meiosis and for organization of the sperm axoneme. These results suggest that centrosomin is a necessary component of the meiotic centrosomes and the spermatid basal body.

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Citations

Mar 20, 2010·Cellular and Molecular Life Sciences : CMLS·Alain DebecMonica Bettencourt-Dias
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·S BhasinB Salehian
Jun 26, 2012·Nature Cell Biology·Jayachandran GopalakrishnanTomer Avidor-Reiss
Mar 27, 2009·Molecular Biology of the Cell·Violaine Mottier-Pavie, Timothy L Megraw
Mar 20, 2010·Molecular Biology of the Cell·Lacramioara FabianJulie A Brill
Dec 15, 2015·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Dorothy A Lerit, John S Poulton
Feb 24, 2016·Tissue & Cell·Romano DallaiPietro Lupetti
Oct 23, 2012·Spermatogenesis·Lacramioara Fabian, Julie A Brill
Apr 21, 2016·Fly·Robert C EismanThomas C Kaufman
Mar 7, 2001·Current Biology : CB·T L MegrawT C Kaufman
Oct 26, 1999·Current Biology : CB·S J Vidwans, P H O'Farrell
Apr 18, 2015·Frontiers in Cell and Developmental Biology·Tomer Avidor-ReissKyoung H Jo
Feb 18, 2003·Molecular Reproduction and Development·April Pyle, Mary Ann Handel
Feb 18, 2014·Genetics·Stephanie BlachonTomer Avidor-Reiss
Dec 18, 2020·Cells·Maria Giovanna RiparbelliGiuliano Callaini
May 11, 2020·Developmental Biology·Elisabeth BauerlyMatthew C Gibson
Jan 18, 2017·Current Biology : CB·Atul KhireTomer Avidor-Reiss
Sep 2, 2004·Journal of Cell Science·Fatima F DonkorSigrid Hoyer-Fender
Nov 5, 2002·Journal of Cell Science·Timothy L MegrawThomas C Kaufman

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