Drosophila clock neurons under natural conditions

Journal of Biological Rhythms
Pamela MenegazziRodolfo Costa

Abstract

The circadian clock modulates the adaptive daily patterns of physiology and behavior and adjusts these rhythms to seasonal changes. Recent studies of seasonal locomotor activity patterns of wild-type and clock mutant fruit flies in quasi-natural conditions have revealed that these behavioral patterns differ considerably from those observed under standard laboratory conditions. To unravel the molecular features accompanying seasonal adaptation of the clock, we investigated Drosophila's neuronal expression of the canonical clock proteins PERIOD (PER) and TIMELESS (TIM) in nature. We find that the profile of PER dramatically changes in different seasons, whereas that of TIM remains more constant. Unexpectedly, we find that PER and TIM oscillations are decoupled in summer conditions. Moreover, irrespective of season, PER and TIM always peak earlier in the dorsal neurons than in the lateral neurons, suggesting a more rapid molecular oscillation in these cells. We successfully reproduced most of our results under simulated natural conditions in the laboratory and show that although photoperiod is the most important zeitgeber for the molecular clock, the flies' activity pattern is more strongly affected by temperature. Our results are...Continue Reading

References

Aug 17, 2001·Journal of Biological Rhythms·E Tauber, B P Kyriacou
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·B H CollinsC P Kyriacou
Mar 19, 2004·Current Biology : CB·Orie T ShaferJeffery C Hall
Jun 3, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shawn A CyranJustin Blau
Feb 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang BachleitnerCharlotte Helfrich-Förster
Apr 19, 2007·Journal of Biological Rhythms·Taishi YoshiiKenji Tomioka
Jun 30, 2007·Science·Federica SandrelliCharalambos P Kyriacou
Sep 19, 2007·Journal of Biological Rhythms·Dirk RiegerCharlotte Helfrich-Förster
May 1, 2009·PLoS Biology·Johannes LandskronRalf Stanewsky
Nov 21, 2009·Journal of Biological Rhythms·Taishi YoshiiCharlotte Helfrich-Förster
Feb 13, 2010·Annual Review of Physiology·Ravi Allada, Brian Y Chung
Mar 1, 2011·FEBS Letters·Luca SchiesariRodolfo Costa
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Taichi HaraAmita Sehgal
Sep 20, 2011·Advances in Genetics·Paul E Hardin
Dec 12, 2012·Journal of Biological Rhythms·Pamela MenegazziCharlotte Helfrich-Förster

❮ Previous
Next ❯

Citations

May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Joydeep DeVijay Kumar Sharma
May 16, 2013·Integrative and Comparative Biology·Benjamin L SmarrHoracio O de la Iglesia
Jul 23, 2014·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Priya M Prabhakaran, Vasu Sheeba
Apr 12, 2016·Communicative & Integrative Biology·Taishi YoshiiCharlotte Helfrich-Förster
Sep 18, 2015·Proceedings. Biological Sciences·Matthias SchlichtingCharlotte Helfrich-Förster
Jul 15, 2015·Journal of Insect Physiology·Alena KobelkovaDavid L Denlinger
Jun 4, 2013·Neuroscience·N I MuraroM F Ceriani
Sep 16, 2014·Current Biology : CB·Stephane DisselEzio Rosato
Feb 20, 2014·Physiology & Behavior·Pankaj Yadav, Vijay Kumar Sharma
May 23, 2015·Journal of Biological Rhythms·Stefano MontelliRodolfo Costa
Mar 7, 2017·Current Biology : CB·Pamela MenegazziCharlotte Helfrich-Förster
May 16, 2018·Journal of Biological Rhythms·Gustavo B S RivasRafaela Vieira Bruno
Aug 24, 2018·Journal of Economic Entomology·José ArredondoFrancisco Díaz-Fleischer
Dec 8, 2017·Physiology·D Lorena FrancoM Fernanda Ceriani
Oct 22, 2013·The Journal of Experimental Biology·Priya M Prabhakaran, Vasu Sheeba

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.