Drosophila CLOCK protein is under posttranscriptional control and influences light-induced activity

Neuron
Eun Young KimI Edery

Abstract

In the Drosophila circadian clock, daily cycles in the RNA levels of dclock (dClk) are antiphase to those of period (per). We altered the timing/levels of dClk expression by generating transgenic flies whereby per circadian regulatory sequences were used to drive rhythmic transcription of dClk. The results indicate that posttranscriptional mechanisms make substantial contributions to the temporal changes in the abundance of the dCLK protein. Circadian regulation is largely unaffected in the transgenic per-dClk flies despite higher mean levels of dCLK. However, in per-dClk flies the duration of morning activity is lengthened in light-dark cycles and light pulses evoke longer lasting bouts of activity. Our findings suggest that, in addition to a role in generating circadian rhythms, dCLK modulates the direct effects of light on locomotion.

References

Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R J Konopka, S Benzer
Aug 1, 1984·Cell·R E Karess, G M Rubin
Oct 22, 1982·Science·G M Rubin, A C Spradling
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·I EderyM Rosbash
Jan 1, 1993·Journal of Biological Rhythms·D A WheelerJ C Hall
Jul 1, 1997·Molecular and Cellular Biology·H HaoP E Hardin
Feb 13, 1999·Cell·J C Dunlap
Aug 12, 1999·Chronobiology International·N Mrosovsky
Mar 9, 2000·Neuron·J C HendricksA I Pack
Mar 10, 2000·Science·P J ShawG Tononi
Mar 23, 2000·Progress in Neurobiology·J C HendricksA I Pack
May 12, 2000·Science·L P ShearmanS M Reppert
Oct 4, 2000·Physiological Genomics·I Edery
Feb 22, 2001·Annual Review of Physiology·J A Williams, A Sehgal
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·P ChengY Liu
Aug 25, 2001·Annual Review of Neuroscience·R AlladaM Rosbash
Sep 5, 2001·Nature Reviews. Genetics·M W Young, S A Kay

❮ Previous
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Citations

Dec 18, 2002·Journal of Neurobiology·Ralf Stanewsky
Nov 24, 2004·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Uwe RedlinN Mrosovsky
Apr 7, 2007·Histochemistry and Cell Biology·Manuela MalatestaCarlo Bertoni-Freddari
Aug 30, 2008·Molecular Neurobiology·Raphaelle Dubruille, Patrick Emery
Jan 25, 2007·Nature Reviews. Molecular Cell Biology·Monica Gallego, David M Virshup
Jan 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Joseph RodriguezMichael Rosbash
Jul 1, 2009·The Journal of Biological Chemistry·Hsiu-Cheng HungFrank Weber
May 15, 2012·Genes & Development·Shailesh KumarAmita Sehgal
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·J BenitoP E Hardin
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·J D Keene
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·C QuerfurthT Schafmeier
Aug 10, 2006·Eukaryotic Cell·Yi Liu, Deborah Bell-Pedersen
Apr 25, 2007·Molecular and Cellular Biology·Chunghun LimJoonho Choe
Nov 11, 2006·Annual Review of Genetics·Herman Wijnen, Michael W Young
Apr 11, 2006·Journal of Biological Rhythms·Jerry H HoulPaul E Hardin
Sep 17, 2009·Journal of Biological Rhythms·Valerie L Kilman, Ravi Allada
Jan 19, 2011·Journal of Cell Science·Shihoko KojimaCarla B Green
May 23, 2008·PLoS Biology·Sebastian KadenerMichael Rosbash
Dec 18, 2013·PLoS Biology·Esteban J BeckwithMaría Fernanda Ceriani
Apr 23, 2009·PloS One·Valerie L KilmanRavi Allada
Nov 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jinli LingPatrick Emery
Oct 12, 2013·Antioxidants & Redox Signaling·Martha U Gillette, Tongfei A Wang
Apr 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Eun Young Kim, Isaac Edery
Apr 12, 2006·Proceedings of the National Academy of Sciences of the United States of America·Irene YujnovskyPaolo Sassone-Corsi
Jan 17, 2009·Journal of Genetics·Manjunatha TVijay Kumar Sharma
Mar 1, 2008·Critical Reviews in Biochemistry and Molecular Biology·Vasu SheebaTodd C Holmes
Mar 1, 2011·FEBS Letters·Luca SchiesariRodolfo Costa
Apr 14, 2011·FEBS Letters·Frank WeberHsiu-Cheng Hung
Jun 15, 2007·Journal of Theoretical Biology·Tanya L Leise, Emily E Moin
Oct 7, 2005·Microscopy Research and Technique·Manuela MalatestaCarlo Bertoni-Freddari
Sep 19, 2008·The EMBO Journal·Marcus P S Dekens, David Whitmore
Aug 21, 2010·Journal of Neurochemistry·Katja SchneiderRainer Spessert
Oct 24, 2007·Biochemical and Biophysical Research Communications·Chunghun LimJoonho Choe
Oct 3, 2006·Current Opinion in Neurobiology·Paul E Hardin
Jul 8, 2003·Microscopy Research and Technique·Manuela MalatestaGiancarlo Gazzanelli
Feb 14, 2012·Chronobiology International·Shweta SharmaDilip Joshi
Apr 29, 2011·EMBO Reports·Angélique LamazeFrançois Rouyer
May 20, 2015·Cell Reports·Simonetta AndreazzaFrançois Rouyer

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