Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation.

Developmental Biology
Adam KleinschmitHiroshi Nakato

Abstract

Heparan sulfate proteoglycans (HSPGs) play critical roles in the distribution and signaling of growth factors, but the molecular mechanisms regulating HSPG function are poorly understood. Here, we characterized Sulf1, which is a Drosophila member of the HS 6-O endosulfatase class of HS modifying enzymes. Our genetic and biochemical analyses show that Sulf1 acts as a novel regulator of the Wg morphogen gradient by modulating the sulfation status of HS on the cell surface in the developing wing. Sulf1 affects gradient formation by influencing the stability and distribution of Wg. We also demonstrate that expression of Sulf1 is induced by Wg signaling itself. Thus, Sulf1 participates in a feedback loop, potentially stabilizing the shape of the Wg gradient. Our study shows that the modification of HS fine structure provides a novel mechanism for the regulation of morphogen gradients.

References

Feb 26, 1993·Cell·G Struhl, K Basler
Apr 4, 2000·Current Biology : CB·M Strigini, S M Cohen
Aug 8, 2001·The Journal of Clinical Investigation·J T Gallagher
Mar 16, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Tatsuyuki OhtoMasayuki Masu
May 10, 2002·Genes & Development·Offer Gerlitz, Konrad Basler
May 23, 2002·Developmental Cell·Antonio J GiráldezStephen M Cohen
Jun 14, 2002·Current Biology : CB·Sven PfeifferJean-Paul Vincent
Oct 9, 2002·The Journal of Biological Chemistry·Megumi Morimoto-TomitaSteven D Rosen
Nov 5, 2002·Developmental Biology·Takashi Adachi-Yamada, Michael B O'Connor
Nov 6, 2002·Biochimica Et Biophysica Acta·Hiroshi Nakato, Koji Kimata
Mar 7, 2003·Development·Momoko FujiseHiroshi Nakato
Apr 11, 2003·The Journal of Biological Chemistry·Jinping LaiViji Shridhar
Feb 6, 2004·Development·Tetsuya Tabata, Yuki Takei
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Shouwen WangCharles P Emerson
Oct 8, 2004·Developmental Cell·Catherine A KirkpatrickScott B Selleck
Jan 14, 2005·Development·Xavier Franch-MarroJean-Paul Vincent
Dec 27, 2005·The Journal of Biological Chemistry·Xingbin AiCharles P Emerson
Sep 13, 2006·The Journal of Cell Biology·Keisuke KamimuraHiroshi Nakato
Oct 24, 2006·Developmental Biology·Catherine A KirkpatrickScott B Selleck
Feb 27, 2007·Trends in Cell Biology·Bushra Gorsi, Sally E Stringer
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Johannes BischofKonrad Basler
May 23, 2007·Journal of Cell Science·Catherine A Kirkpatrick, Scott B Selleck
Dec 7, 2007·Developmental Biology·Takuya AkiyamaHiroshi Nakato
Jul 12, 2008·Developmental Biology·Stephen D FreemanMary E Pownall
Aug 15, 2008·Nature·Xiaomeng WangHilary L Ashe
Jun 13, 2009·The Journal of Biological Chemistry·Renhong Tang, Steven D Rosen

❮ Previous
Next ❯

Citations

Aug 2, 2011·Annual Review of Cell and Developmental Biology·Katherine W Rogers, Alexander F Schier
Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Isao Matsuo, Chiharu Kimura-Yoshida
Jan 10, 2013·The Journal of Biological Chemistry·Adam KleinschmitHiroshi Nakato
Jan 23, 2013·The Journal of Biological Chemistry·Katsufumi DejimaHiroshi Nakato
Sep 21, 2013·Disease Models & Mechanisms·Samuel H FriedmanKendal Broadie
Jan 23, 2016·Molecular Biology of the Cell·Daniel C LevingsHiroshi Nakato
Oct 18, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rita A Buresh-StiemkePaul C Marker
Aug 3, 2011·Developmental Biology·Alexandre WojcinskiBruno Glise
Jul 19, 2011·Developmental Cell·Patrick Müller, Alexander F Schier
Jul 8, 2016·International Journal of Experimental Pathology·Vivien Jane Coulson-Thomas
Nov 5, 2016·Glycoconjugate Journal·Rana El MasriRomain R Vivès
Jun 25, 2017·Biochimica Et Biophysica Acta. General Subjects·Keisuke Kamimura, Nobuaki Maeda
Sep 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Amy R PoeChun Han
Jun 15, 2018·Proceedings of the National Academy of Sciences of the United States of America·Kristian K KristensenMichael Ploug
Nov 27, 2016·Journal of Cell Science·Masahiko Takemura, Hiroshi Nakato
Mar 1, 2018·Scientific Reports·Makoto I KanaiHiroshi Nakato
Apr 22, 2011·Developmental Neurobiology·Neil Dani, Kendal Broadie
Jan 9, 2020·Journal of Cell Communication and Signaling·Sitong ShenYan Zhang
Feb 13, 2020·Molecular Biology of the Cell·Masahiko TakemuraHiroshi Nakato
May 19, 2012·Genetics·Jonathan P ButcharAmanda Simcox
Jan 6, 2017·Journal of Biochemistry·Shinji TakadaYusuke Mii
Nov 28, 2019·Glycoconjugate Journal·Shoko Nishihara
Sep 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thibault AnnavalHugues Lortat-Jacob
Jul 3, 2019·Biology·George A McCanneySusan C Barnett
Mar 27, 2018·Current Opinion in Structural Biology·Robert A Townley, Hannes E Bülow
Feb 15, 2015·Journal of Cell Science·Simon W FellgettMary Elizabeth Pownall
Oct 25, 2012·Development·Yoshiki HayashiDouglas A Harrison

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Jia YouXinhua Lin
Journal of Cell Science
Xavier Franch-MarroJean-Paul Vincent
© 2021 Meta ULC. All rights reserved