Drosophila homolog of APP-BP1 (dAPP-BP1) interacts antagonistically with APPL during Drosophila development.

Cell Death and Differentiation
H-J KimJ Yim

Abstract

beta-Amyloid precursor protein binding protein 1 (APP-BP1) was previously identified based on its binding to the carboxyl terminal of beta-amyloid precursor protein. In this report, we have discovered that a mutation of dAPP-BP1 (Drosophila ortholog of APP-BP1) hinders tissue development, causes apoptosis in imaginal disc cells, and blocks the NEDD8 conjugation pathway. We show that dAPP-BP1 specifically binds the intracellular domain of APP-like protein (APPL). The dAPP-BP1 mutation partially suppresses the abnormal macrochaete phenotype of Appl(d), while overexpression of dAPP-BP1 causes abnormal macrochaetes. When APPL is overexpressed, the normal bristle pattern in the fly thorax is disturbed and apoptosis is induced in wing imaginal discs. APPL overexpression phenotypes are enhanced by reducing the level of dAPP-BP1. APPL overexpression is shown to inhibit the NEDD8 conjugation pathway. APPL-induced apoptosis is rescued by overexpression of dAPP-BP1. Our data suggest that APPL and dAPP-BP1 interact antagonistically during Drosophila development.

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Citations

Mar 6, 2012·Human Molecular Genetics·Yeun Su ChooZhuohua Zhang
Dec 12, 2007·Journal of Neuroinflammation·Yuzhi Chen, Angela M Bodles
Feb 9, 2007·Molecular Neurodegeneration·Yuzhi ChenW Sue T Griffin
Feb 21, 2008·PloS One·Marta Vicente-CrespoRuben D Artero
Sep 14, 2011·Experimental Brain Research·Burkhard PoeckDoris Kretzschmar
Jul 2, 2011·Toxicon : Official Journal of the International Society on Toxinology·Xiang MengShunxiang Ren
Jul 19, 2012·Journal of Cellular and Molecular Medicine·Yuzhi ChenHelena Liu
Mar 6, 2015·Apoptosis : an International Journal on Programmed Cell Death·Xingjun WangLei Xue
May 30, 2001·Journal of Dermatological Science·T Ohsawa
Aug 18, 2004·Progress in Neurobiology·Ashok N Hegde
Jun 20, 2018·Scientific Reports·Zhongqi HeHeping Cao
Sep 11, 2008·Journal of Cell Science·Yaru ChanCheng-Ting Chien

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