Drosophila immune priming against Pseudomonas aeruginosa is short-lasting and depends on cellular and humoral immunity

F1000Research
Theodoulakis Christofi, Yiorgos Apidianakis

Abstract

Immune responses are traditionally divided into the innate and the adaptive arm, both of which are present in vertebrates, while only the innate arm is found in invertebrates. Immune priming experiments in Drosophila melanogaster and other invertebrates during the last decade have challenged this dogma, questioning the boundaries between innate and adaptive immunity. Studies on repeated inoculation of Drosophila with microbes reveal a long-lasting cellular immunity adaptation against particular microorganisms. Here we study the lasting effect of immune priming against infection with Pseudomonas aeruginosa, an opportunistic human pathogen that is lethal to the common fruit fly. Drosophila priming with heat-killed or low in virulence P. aeruginosa extends fly survival during a secondary lethal infection with a virulent strain of the same species. The protective immune response can last for more than 10 days after exposure to a persistent low-in-virulence live infection, but it is eliminated 7 days after the host is primed with heat-killed bacteria. Moreover, not only the cellular, but also the systemic NF-κB-mediated immune responses contribute to immune priming. Thus each microbe might elicit different mechanisms of immune primi...Continue Reading

References

Feb 1, 1996·Current Opinion in Immunology·T Muta, S Iwanaga
Dec 12, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M MeisterJ A Hoffmann
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z Pancer
Feb 20, 2003·The Journal of Allergy and Clinical Immunology·Rafeul Alam, Magdalena Gorska
Jul 23, 2003·Nature Immunology·Alexander N R WeberNicholas J Gay
Dec 12, 2003·Proceedings. Biological Sciences·Yannick Moret, Michael T Siva-Jothy
Dec 31, 2003·Molecular Immunology·Bruce Beutler
Jul 13, 2004·Science·Si-Ming ZhangEric S Loker
Sep 30, 2004·Nature Immunology·Michael C Carroll
Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yiorgos ApidianakisLaurence G Rahme
Mar 9, 2005·Immunology Letters·B Paul MorganAwen M Gallimore
Aug 20, 2005·Science·Fiona L WatsonDietmar Schmucker
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Isabelle Jutras, Michel Desjardins
Feb 4, 2006·The Journal of Allergy and Clinical Immunology·David D Chaplin
Jan 5, 2007·Annual Review of Immunology·Bruno Lemaitre, Jules Hoffmann
Mar 14, 2007·PLoS Pathogens·Linh N PhamDavid S Schneider
Aug 15, 2009·Nature Protocols·Yiorgos Apidianakis, Laurence G Rahme
Jan 7, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanna ValanneMika Rämet
Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Takayuki KuraishiBruno Lemaitre
Oct 23, 2012·Cell Host & Microbe·Junaid Ziauddin, David S Schneider

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Citations

Jul 19, 2014·Developmental and Comparative Immunology·C M Adema, E S Loker
Sep 3, 2013·Current Opinion in Pharmacology·Ilias TzelepisYiorgos Apidianakis
Feb 24, 2015·Immunology Letters·Gustav van Niekerk, Anna-Mart Engelbrecht
Jul 26, 2016·Frontiers in Microbiology·Valeria VargasHumberto Lanz-Mendoza
Oct 28, 2019·PloS One·Moria Cairns ChambersBrian P Lazzaro
Nov 10, 2020·Cell and Tissue Research·Valéria Aparecida BeloLeonardo Augusto de Almeida

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