Drosophila Incenp is required for cytokinesis and asymmetric cell division during development of the nervous system

Journal of Cell Science
Chih-Jui ChangM Carmena

Abstract

The chromosomal passenger protein complex has emerged as a key player in mitosis, with important roles in chromatin modifications, kinetochore-microtubule interactions, chromosome bi-orientation and stability of the bipolar spindle, mitotic checkpoint function, assembly of the central spindle and cytokinesis. The inner centromere protein (Incenp; a subunit of this complex) is thought to regulate the Aurora B kinase and target it to its substrates. To explore the roles of the passenger complex in a developing multicellular organism, we have performed a genetic screen looking for new alleles and interactors of Drosophila Incenp. We have isolated a new null allele of Incenp that has allowed us for the first time to study the functions of the chromosomal passengers during development. Homozygous incenp(EC3747) embryos show absence of phosphorylation of histone H3 in mitosis, failure of cytokinesis and polyploidy, and defects in peripheral nervous system development. These defects are consistent with depletion of Aurora B kinase activity. In addition, the segregation of the cell-fate determinant Prospero in asymmetric neuroblast division is abnormal, suggesting a role for the chromosomal passenger complex in the regulation of this p...Continue Reading

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Citations

Sep 13, 2007·Nature Reviews. Molecular Cell Biology·Sandrine RuchaudWilliam C Earnshaw
Nov 24, 2012·Nature Reviews. Molecular Cell Biology·Mar CarmenaWilliam C Earnshaw
Jul 24, 2012·Genes & Genetic Systems·Yuki Ogiyama, Kojiro Ishii
Aug 14, 2012·Cytoskeleton·Clemens Cabernard
Mar 14, 2008·Mechanisms of Development·Yasunari YamanakaTatsutoshi Nakahata
Jul 12, 2011·Physiological Reviews·Marcos Malumbres
Apr 10, 2021·The Journal of Cell Biology·Lin-Ing WangKim S McKim

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