Drosophila Insulin receptor regulates the persistence of injury-induced nociceptive sensitization.

Disease Models & Mechanisms
Seol Hee ImMichael J Galko

Abstract

Diabetes-associated nociceptive hypersensitivity affects diabetic patients with hard-to-treat chronic pain. Because multiple tissues are affected by systemic alterations in insulin signaling, the functional locus of insulin signaling in diabetes-associated hypersensitivity remains obscure. Here, we used Drosophila nociception/nociceptive sensitization assays to investigate the role of Insulin receptor (Insulin-like receptor, InR) in nociceptive hypersensitivity. InR mutant larvae exhibited mostly normal baseline thermal nociception (absence of injury) and normal acute thermal hypersensitivity following UV-induced injury. However, their acute thermal hypersensitivity persists and fails to return to baseline, unlike in controls. Remarkably, injury-induced persistent hypersensitivity is also observed in larvae that exhibit either type 1 or type 2 diabetes. Cell type-specific genetic analysis indicates that InR function is required in multidendritic sensory neurons including nociceptive class IV neurons. In these same nociceptive sensory neurons, only modest changes in dendritic morphology were observed in the InRRNAi -expressing and diabetic larvae. At the cellular level, InR-deficient nociceptive sensory neurons show elevated cal...Continue Reading

References

Jan 1, 1985·Acta Neuropathologica·H C PowellR R Myers
Mar 1, 1996·Endocrinology·C ChenR S Garofalo
Oct 1, 1996·Neurology·W R KennedyT Johnson
Apr 28, 2000·Science·T ZarsM Heisenberg
Oct 12, 2000·Diabetes/metabolism Research and Reviews·K SugimotoA A Sima
Apr 10, 2002·Journal of the Peripheral Nervous System : JPNS·Kazuhiro SugimotoAnders A F Sima
Sep 6, 2003·Current Biology : CB·Joshua A AinsleyWayne A Johnson
Jun 29, 2004·Diabetes·Valentine BrusseeDouglas W Zochodne
Nov 27, 2004·Nature Genetics·Robert J WessellsRolf Bodmer
Sep 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Qi WuPing Shen
Oct 6, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alfonso Martín-PeñaAlberto Ferrús
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wei SongYuh Nung Jan
Nov 29, 2007·Journal of the Peripheral Nervous System : JPNS·Douglas E WrightJanelle M Ryals
Dec 7, 2007·Current Biology : CB·Richard Y HwangW Daniel Tracey
Aug 30, 2008·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Yonghua WangZhaohui Wang
Oct 2, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Aristidis VevesRayaz A Malik
Apr 21, 2009·Current Biology : CB·Daniel T BabcockMichael J Galko
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Irina G Obrosova
Dec 17, 2009·The Biochemical Journal·Aurelio A Teleman
Mar 3, 2010·Communicative & Integrative Biology·Daniel T Babcock, Michael J Galko
Oct 16, 2010·Nature Medicine·Michael S Gold, Gerald F Gebhart
Apr 5, 2011·Nature Methods·Jian-Quan NiNorbert Perrimon
Jul 2, 2011·Disease Models & Mechanisms·Laura Palanker MusselmanThomas J Baranski
Aug 4, 2011·Endocrinology·Bhumsoo KimEva L Feldman
Sep 13, 2011·Current Biology : CB·Daniel T BabcockMichael J Galko
Sep 21, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Seol Hee Im, Michael J Galko
May 1, 2012·Biochimica Et Biophysica Acta·Siti Nur Sarah MorrisJohannes H Bauer
May 31, 2012·Journal of Visualized Experiments : JoVE·Abanti ChattopadhyayMichael J Galko
Jan 18, 2013·PLoS Genetics·Jianbo NaRoss Cagan
Jul 23, 2013·Nature·Tsai-Wen ChenDouglas S Kim

❮ Previous
Next ❯

Citations

Oct 24, 2019·The Journal of Comparative Neurology·Ritwika Mukherjee, Barry A Trimmer
Sep 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Roger Lopez-BellidoMichael J Galko
Sep 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nathaniel J HimmelDaniel N Cox
Sep 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thang M KhuongG Gregory Neely
May 10, 2019·Development·Hanna ReuterFlorenci Serras
May 17, 2019·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yasutetsu KanaokaYukako Hattori

❮ Previous
Next ❯

Software Mentioned

ImageJ
CaMPARI
GraphPad Prism
Adobe Photoshop

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

Journal - Canadian Dental Association = Journal De L'Association Dentaire Canadienne
N F Katsikeris, M F Caminiti
American Journal of Clinical Pathology
S Charache
American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
Winnie W NelsonJeffery R Schein
© 2022 Meta ULC. All rights reserved