Drosophila melanogaster antimicrobial defense

The Journal of Infectious Diseases
Charles HetruJules A Hoffmann

Abstract

The Drosophila melanogaster host defense is complex but remarkably efficient. It is a multifaceted response to a variety of fungal, bacterial, and parasitic invaders. Current knowledge is discussed on recognition of infectious microorganisms and on the activation of intracellular signaling cascades that concur with the expression of numerous immune-responsive genes, among which, to date, the most prominent appear to encode potent antimicrobial peptides.

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Related Concepts

Bacterial Infections
Drosophila melanogaster
Resistance, Natural
Mycoses
Parasitic Diseases, Animal
Polypeptides
Signal Transduction

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