Drosophila melanogaster antimicrobial defense

The Journal of Infectious Diseases
Charles HetruJules A Hoffmann


The Drosophila melanogaster host defense is complex but remarkably efficient. It is a multifaceted response to a variety of fungal, bacterial, and parasitic invaders. Current knowledge is discussed on recognition of infectious microorganisms and on the activation of intracellular signaling cascades that concur with the expression of numerous immune-responsive genes, among which, to date, the most prominent appear to encode potent antimicrobial peptides.


Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·Bruno LemaitreJ A Hoffmann
Jan 1, 1995·Advances in Immunology·E B Kopp, S Ghosh
Jul 20, 1993·Journal of Molecular Biology·Y EngströmI Faye
Jun 7, 1996·The Journal of Biological Chemistry·H YoshidaM Ashida
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·M S DushayDan Hultmark
Jan 1, 1996·Annual Review of Cell and Developmental Biology·Marcia Belvin, Kathryn V Anderson
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·Bruno LemaitreJ A Hoffmann
Aug 11, 1998·Trends in Biochemical Sciences·K MizuguchiN J Gay
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·D KangH Steiner
Oct 2, 1998·Insect Biochemistry and Molecular Biology·O Marcu, M Locke
Feb 27, 1999·Current Opinion in Immunology·R I Lehrer, T Ganz
May 21, 1999·Science·J A HoffmannR Alan B Ezekowitz
Jun 23, 1999·Molecular Medicine Today·T Ganz, R I Lehrer
Jul 20, 1999·The Journal of Biological Chemistry·Z S Han, Y Tony Ip
Jul 30, 1999·Developmental and Comparative Immunology·P BuletD Hoffmann
Jul 30, 1999·Developmental and Comparative Immunology·Y Engström
Nov 24, 1999·Insect Biochemistry and Molecular Biology·S Ekengren, Dan Hultmark
Feb 19, 2000·Current Opinion in Microbiology·J L Imler, J A Hoffmann
Jul 19, 2000·Current Biology : CB·M Elrod-EricksonD Schneider
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·S TauszigJ L Imler
Mar 23, 2001·Nature Immunology·S RutschmannDominique Ferrandon
Dec 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·Thomas WernerDan Hultmark
Jan 13, 2001·Current Opinion in Immunology·J CohnG B Martin
Jan 13, 2001·Current Opinion in Immunology·B P ThommaB P Cammue
Mar 28, 2001·EMBO Reports·François LeulierBruno Lemaitre
Apr 3, 2001·Nature Reviews. Genetics·D A Kimbrell, B Beutler
Jun 20, 2001·Trends in Cell Biology·J L Imler, J A Hoffmann
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·Ennio De GregorioBruno Lemaitre
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·P IrvingCharles Hetru
Dec 18, 2001·Nature Immunology·Servane Tauszig-DelamasureJean-Luc Imler
Dec 26, 2001·EMBO Reports·James Y OoiY Tony Ip
Jan 29, 2002·Nature Immunology·Jules A Hoffmann, Jean-Marc Reichhart
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Phoebe TzouBruno Lemaitre
May 29, 2002·The EMBO Journal·Ennio De GregorioBruno Lemaitre
Jul 6, 2002·Science·Petros LigoxygakisJean-Marc Reichhart
Mar 6, 2003·Gene Expression Patterns : GEP·Zakaria KambrisMaria Capovilla
Aug 1, 1997·Trends in Cell Biology·J A Hergannan, J V Rechhart


Mar 24, 2004·Current Opinion in Microbiology·Elizabeth A McGraw, Scott L O'Neill
Mar 31, 2004·Microbes and Infection·John GerrardRichard ffrench-Constant
Jun 15, 2010·The Journal of Antimicrobial Chemotherapy·Anders S AndersenKaren A Krogfelt
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Charles Hetru, Jules A Hoffmann
Apr 13, 2004·Eukaryotic Cell·Yiorgos ApidianakisEleftherios Mylonakis
Sep 16, 2004·Journal of Virology·Javier RobalinoGregory W Warr
Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yiorgos ApidianakisLaurence G Rahme
Oct 4, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E Andrès
Apr 26, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Kazuhiko HashimotoIsao Morishima
Feb 20, 2007·Médecine et maladies infectieuses·E Andrès, J-L Dimarcq
Nov 7, 2003·Developmental Cell·Cory J EvansUtpal Banerjee
Mar 12, 2005·Cellular Microbiology·Takashi Kaneko, Neal Silverman
Jun 18, 2004·Immunological Reviews·G K ChristophidesFotis C Kafatos
Jun 18, 2004·Immunological Reviews·Hinrich SchulenburgJonathan J Ewbank
Feb 5, 2008·Cellular Microbiology·Anastasia Levitin, Malcolm Whiteway
Dec 21, 2007·Insect Molecular Biology·L C BartholomayB M Christensen
Apr 23, 2013·Archives of Insect Biochemistry and Physiology·Shunsuke X FurihataYoichi Hayakawa
Dec 8, 2004·International Journal for Parasitology·S MeisterG K Christophides
Aug 25, 2004·Trends in Parasitology·Michael J LehaneElena Levashina
Sep 15, 2004·La Revue de médecine interne·E Andrès, J-L Dimarcq
May 30, 2006·Journal of Insect Physiology·Małgorzata CytryńskaTeresa Jakubowicz
Jul 18, 2006·Journal of Insect Physiology·A Córdoba-AguilarF Ascencio
Feb 27, 2016·Genes, Brain, and Behavior·B R TroutwineN S Atkinson
Jul 9, 2013·Microbes and Infection·Chun-Taek OhJichan Jang
Sep 21, 2011·Developmental and Comparative Immunology·Susanna ValanneMika Rämet
Feb 9, 2007·Molecular Immunology·Jingqun AoXiao-Qiang Yu
Sep 10, 2014·Frontiers in Cellular and Infection Microbiology·Alexis A Smith, Utpal Pal
Dec 9, 2008·Journal of Medical Entomology·G F Martins, P F P Pimenta
Jun 17, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yoirentomba Meetei SinamUpendra Nongthomba
Mar 2, 2002·The Lancet Infectious Diseases·R E Hancock
Jul 27, 2004·Archives of Insect Biochemistry and Physiology·Iwona WojdaTeresa Jakubowicz
Jan 15, 2015·Antimicrobial Agents and Chemotherapy·Elamparithi JayamaniEleftherios Mylonakis
Nov 15, 2006·Archives of Insect Biochemistry and Physiology·S Hernández-MartínezH Lanz-Mendoza
Nov 2, 2018·Asian-Australasian Journal of Animal Sciences·Yeojin HongYeong Ho Hong
Jun 14, 2018·Frontiers in Cellular and Infection Microbiology·Chrysoula Kitsou, Utpal Pal
Nov 11, 2018·Toxins·Qinghua WuKamil Kuča
Aug 24, 2018·International Journal of Molecular Sciences·Kyung-Jin Min, Marc Tatar
Sep 19, 2020·Journal of Invertebrate Pathology·Tao GengShuchang Wang

Related Concepts

Bacterial Infections
Drosophila melanogaster
Resistance, Natural
Parasitic Diseases, Animal
Signal Transduction

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.