Drosophila melanogaster as a model for lead neurotoxicology and toxicogenomics research.

Frontiers in Genetics
Helmut V B HirschDouglas M Ruden

Abstract

Drosophila melanogaster is an excellent model animal for studying the neurotoxicology of lead. It has been known since ancient Roman times that long-term exposure to low levels of lead results in behavioral abnormalities, such as what is now known as attention deficit hyperactivity disorder (ADHD). Because lead alters mechanisms that underlie developmental neuronal plasticity, chronic exposure of children, even at blood lead levels below the current CDC community action level (10 μg/dl), can result in reduced cognitive ability, increased likelihood of delinquency, behaviors associated with ADHD, changes in activity level, altered sensory function, delayed onset of sexual maturity in girls, and changes in immune function. In order to better understand how lead affects neuronal plasticity, we will describe recent findings from a Drosophila behavioral genetics laboratory, a Drosophila neurophysiology laboratory, and a Drosophila quantitative genetics laboratory who have joined forces to study the effects of lead on the Drosophila nervous system. Studying the effects of lead on Drosophila nervous system development will give us a better understanding of the mechanisms of Pb neurotoxicity in the developing human nervous system.

Citations

Oct 24, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Robert R H Anholt, Trudy F C Mackay
Oct 14, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Aruo NanYiguo Jiang
Jul 8, 2017·International Journal of Molecular Sciences·Pablo Calap-QuintanaMaría Dolores Moltó
Nov 17, 2020·Frontiers in Genetics·Temitope H AdebamboAdebayo A Otitoloju
May 1, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Xiaoyu YuChunfeng Zhu
Sep 17, 2021·Molecular Neurobiology·Olakkaran ShilpaHunasanahally Puttaswamygowda Gurushankara

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-seq
metabolomics profiling

Software Mentioned

QTL
R
MEME ( Multiple Em for Motif Elicitation

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

Child and Adolescent Psychiatry and Mental Health
Jillian C Strayhorn, Joseph M Strayhorn
International Journal of Environmental Research and Public Health
David C Bellinger
Neuromolecular Medicine
Jonna KuntsiPhilip Asherson
© 2021 Meta ULC. All rights reserved