Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesis.

The Journal of Cell Biology
William ChiaHongyan Wang

Abstract

Over the past decade, many of the key components of the genetic machinery that regulate the asymmetric division of Drosophila melanogaster neural progenitors, neuroblasts, have been identified and their functions elucidated. Studies over the past two years have shown that many of these identified components act to regulate the self-renewal versus differentiation decision and appear to function as tumor suppressors during larval nervous system development. In this paper, we highlight the growing number of molecules that are normally considered to be key regulators of cell cycle events/progression that have recently been shown to impinge on the neuroblast asymmetric division machinery to control asymmetric protein localization and/or the decision to self-renew or differentiate.

References

Dec 1, 1991·Genes & Development·S LlamazaresC E Sunkel
Nov 13, 1998·The Journal of Cell Biology·M CarmenaD M Glover
Oct 2, 2002·Nature Genetics·Jacquelyn BondC Geoffrey Woods
Jan 13, 2004·Science·Yoshiyuki KonishiAzad Bonni
Mar 17, 2004·The Journal of Biological Chemistry·Kiyohiro AndoAkira Nakagawara
Sep 6, 2005·Nature Genetics·Emmanuel Caussinus, Cayetano Gonzalez
Nov 9, 2005·Mechanisms of Development·Mara S Almeida, Sarah J Bray
Jun 3, 2006·Developmental Cell·Sarah K BowmanJuergen A Knoblich
Aug 10, 2006·Nature Reviews. Molecular Cell Biology·Jan-Michael Peters
Oct 3, 2006·Developmental Cell·Wigard P Kloosterman, Ronald H A Plasterk
Dec 22, 2006·Genes & Development·Hongyan WangWilliam Chia
Jan 24, 2007·Developmental Biology·Michelle BeaucherAllen Shearn
Feb 21, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Boris EggerAndrea H Brand

❮ Previous
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Citations

May 28, 2011·Cell Death and Differentiation·C Royer, X Lu
Jan 29, 2013·Nature Cell Biology·J JanuschkeC Gonzalez
Mar 17, 2011·Nature Communications·Jens JanuschkeCayetano Gonzalez
Apr 12, 2013·Nature Communications·Bridget E LaMonicaArnold R Kriegstein
May 11, 2013·Nature Protocols·Heike HarzerJuergen A Knoblich
Nov 26, 2008·Oncogene·J Januschke, C Gonzalez
Apr 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Zhong ChenFrederic Berger
Dec 5, 2009·Proceedings of the National Academy of Sciences of the United States of America·Louis-Jan PilazColette Dehay
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Soyoung KimMasaki Shirayama
Apr 22, 2011·Molecular Biology of the Cell·Gérard PrulièreJanet Chenevert
May 28, 2010·Human Molecular Genetics·Matthew A CallanDaniela C Zarnescu
Jul 16, 2008·Molecular Biology and Evolution·Tobias H KloepperDirk Fasshauer
Feb 26, 2010·Cold Spring Harbor Perspectives in Biology·Yukiko M YamashitaAlan J Hunt
Dec 3, 2009·Genes & Development·Ralph A Neumüller, Juergen A Knoblich
May 22, 2009·Plant Physiology·Véronique BoudolfLieven De Veylder
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Michalis Agathocleous, William A Harris
Jan 10, 2008·Annual Review of Cell and Developmental Biology·Shahragim TajbakhshIsabelle Le Roux
Feb 6, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dariush EtemadmoghadamUNKNOWN AOCS Study Group
Dec 3, 2010·Developmental Neuroscience·Hongxing GuiChih-Cheng Tsai
Apr 12, 2011·Cell Structure and Function·Akihito Kawamori, Masamitsu Yamaguchi
Jan 19, 2012·PloS One·Jonathon F Mauser, Kenneth E Prehoda
Oct 17, 2012·PloS One·Peter KreyssigPeter Dittrich
Jun 11, 2014·BMC Bioinformatics·Thilakam MuraliRussell L Finley
Dec 25, 2008·Journal of Neurogenetics·Anna Hovhanyan, Thomas Raabe
Mar 3, 2010·The Journal of Cell Biology·Jens Januschke, Cayetano Gonzalez
Jan 30, 2008·The Journal of Cell Biology·Haifan Lin
Nov 16, 2011·The Journal of Cell Biology·Ana CarmenaStephan Speicher
Jul 1, 2014·IUBMB Life·Sourajit Soumyaranjan DasDebasmita Pankaj Alone
Dec 23, 2015·Development, Growth & Differentiation·Tetsuo Yasugi, Takashi Nishimura
Feb 28, 2015·Progress in Biophysics and Molecular Biology·Bashar Ibrahim
Feb 26, 2011·Trends in Cell Biology·K Adam Bohnert, Kathleen L Gould
Jan 19, 2010·Current Opinion in Neurobiology·Rita Sousa-NunesAlex P Gould
Jun 3, 2008·Current Opinion in Neurobiology·Weimin Zhong, William Chia
Jun 17, 2008·Current Opinion in Immunology·Kendra L Congdon, Tannishtha Reya
May 31, 2008·Current Opinion in Cell Biology·Franck Coumailleau, Marcos González-Gaitán

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Methods Mentioned

BETA
nucleotide exchange
ubiquitination

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