Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development.

Genetics
D F Lyman, B Yedvobnick

Abstract

The neurogenic Notch locus of Drosophila encodes a receptor necessary for cell fate decisions within equivalence groups, such as proneural clusters. Specification of alternate fates within clusters results from inhibitory communication among cells having comparable neural fate potential. Genetically, Hairless (H) acts as an antagonist of most neurogenic genes and may insulate neural precursor cells from inhibition. H function is required for commitment to the bristle sensory organ precursor (SOP) cell fate and for daughter cell fates. Using Notch gain-of-function alleles and conditional expression of an activated Notch transgene, we show that enhanced signaling produces H-like loss-of-function phenotypes by suppressing bristle SOP cell specification or by causing an H-like transformation of sensillum daughter cell fates. Furthermore, adults carrying Notch gain of function and H alleles exhibit synergistic enhancement of mutant phenotypes. Over-expression of an H+ transgene product suppressed virtually all phenotypes generated by Notch gain-of-function genotypes. Phenotypes resulting from over-expression of the H+ transgene were blocked by the Notch gain-of-function products, indicating a balance between Notch and H activity. Th...Continue Reading

Citations

Sep 24, 2008·International Journal of Biological Macromolecules·Daniel Paz-GómezAlejandro Bravo-Patiño
Nov 5, 2005·Journal of Cellular Physiology·Silvia BianchiAntonio Federico
Feb 1, 1997·Current Opinion in Neurobiology·M VervoortA Ghysen
Apr 30, 2008·Genesis : the Journal of Genetics and Development·Annette L ParksMarc A T Muskavitch
Aug 11, 2011·Development·Emma R AnderssonUrban Lendahl
Sep 23, 2021·Disease Models & Mechanisms·Anabel Martinez Lyons, Luke Boulter
Oct 30, 2009·Journal of Neurogenetics·Benjamin Lovegren de BivortYi Zhong
Nov 9, 2010·Mechanisms of Development·David D O'KeefeLeslie J Saucedo

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