Drosophila Rhodopsin 7 can partially replace the structural role of Rhodopsin 1, but not its physiological function

Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
Rudi GreblerCharlotte Helfrich-Förster

Abstract

Rhodopsin 7 (Rh7), a new invertebrate Rhodopsin gene, was discovered in the genome of Drosophila melanogaster in 2000 and thought to encode for a functional Rhodopsin protein. Indeed, Rh7 exhibits most hallmarks of the known Rhodopsins, except for the G-protein-activating QAKK motif in the third cytoplasmic loop that is absent in Rh7. Here, we show that Rh7 can partially substitute Rh1 in the outer receptor cells (R1-6) for rhabdomere maintenance, but that it cannot activate the phototransduction cascade in these cells. This speaks against a role of Rh7 as photopigment in R1-6, but does not exclude that it works in the inner photoreceptor cells.

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Citations

Aug 26, 2017·Journal of Biological Rhythms·Christa KistenpfennigCharlotte Helfrich-Förster
Nov 7, 2019·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Charlotte Helfrich-Förster
Jan 13, 2019·Biology·Pingkalai R SenthilanCharlotte Helfrich-Förster
Oct 6, 2020·Frontiers in Physiology·Gabriella M MazzottaPaola Cusumano
Sep 27, 2018·Clocks & Sleep·Sevag KaladchibachiFabian Fernandez

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Methods Mentioned

BETA
transgenic
PCR
transgenics
PCRs
confocal microscopy

Software Mentioned

ImageJ

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