PMID: 2497103May 1, 1989Paper

Drosophila spectrin: the membrane skeleton during embryogenesis

The Journal of Cell Biology
T C PesacretaD Branton

Abstract

The distribution of alpha-spectrin in Drosophila embryos was determined by immunofluorescence using affinity-purified polyclonal or monoclonal antibodies. During early development, spectrin is concentrated near the inner surface of the plasma membrane, in cytoplasmic islands around the syncytial nuclei, and, at lower concentrations, throughout the remainder of the cytoplasm of preblastoderm embryos. As embryogenesis proceeds, the distribution of spectrin shifts with the migrating nuclei toward the embryo surface so that, by nuclear cycle 9, a larger proportion of the spectrin is concentrated near the plasma membrane. During nuclear cycles 9 and 10, as the nuclei reach the cell surface, the plasma membrane-associated spectrin becomes concentrated into caps above the somatic nuclei. Concurrent with the mitotic events of the syncytial blastoderm period, the spectrin caps elongate at interphase and prophase, and divide as metaphase and anaphase progress. During cellularization, the regions of spectrin concentration appear to shift: spectrin increases near the growing furrow canal and concomitantly increases at the embryo surface. In the final phase of furrow growth, the shift in spectrin concentration is reversed: spectrin decrease...Continue Reading

References

Jan 1, 1988·Cell Motility and the Cytoskeleton·J L Lessard
Jan 1, 1986·Journal of Cellular Biochemistry·R C Langley, C M Cohen
Mar 1, 1988·The Journal of Cell Biology·B J Del BuonoR A Schlegel
Apr 1, 1986·The Journal of Cell Biology·T L Karr, B M Alberts
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K SobueY Fujio
Nov 1, 1987·The Journal of Cell Biology·R DubreuilD P Kiehart
Dec 5, 1986·Science·A ElgsaeterD Branton
Aug 1, 1985·The Journal of Cell Biology·L Y BourguignonJ R Glenney
Jan 1, 1985·Annual Review of Cell Biology·V T Marchesi
Dec 1, 1971·Developmental Biology·S L Fullilove, A G Jacobson
Jan 1, 1984·The Journal of Cell Biology·R M WarnS Webb
Nov 22, 1984·Nature·A J Baines

❮ Previous
Next ❯

Citations

May 24, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L L Dobens, L A Raftery
Apr 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E L Bearer
Jan 1, 1991·Cell Motility and the Cytoskeleton·L D'AndreaE M Bonder
Jan 1, 1995·Developmental Genetics·H Lin, A C Spradling
Aug 1, 1992·Molecular Reproduction and Development·S Galewsky, R A Schulz
Dec 1, 1992·Cell and Tissue Research·G Callaini, M G Riparbelli
Jan 1, 1994·Micron : the International Research and Review Journal for Microscopy·N AlmqvistS Fredriksson
Feb 1, 1996·Current Opinion in Cell Biology·M S LongtineJ R Pringle
Dec 20, 2007·Arthropod Structure & Development·R Rübsam, J Büning
Nov 1, 1990·The Journal of Cell Biology·R R DubreuilD P Kiehart
Dec 1, 1992·The Journal of Cell Biology·V M Fowler, E J Adam
Dec 1, 1993·The Journal of Cell Biology·J K LeeD Branton
Jan 1, 1995·The Journal of Cell Biology·H DengD Branton
Oct 1, 1995·The Journal of Cell Biology·K G Miller, D P Kiehart
Dec 1, 1995·Molecular Biology of the Cell·H FaresJ R Pringle
Mar 12, 2003·Genes & Development·Frieder Schöck, Norbert Perrimon
Feb 12, 2009·Development, Growth & Differentiation·Vyacheslav Dyachuk, Nelly Odintsova
Jan 1, 1990·Annals of the New York Academy of Sciences·D P KiehartC T Stewart
Nov 13, 1998·The Journal of Cell Biology·M CarmenaD M Glover
May 8, 2002·The Journal of Cell Biology·Kenneth R Norman, Donald G Moerman
Apr 22, 2011·Developmental Neurobiology·Bernd Goellner, Hermann Aberle
Feb 1, 1991·Current Opinion in Cell Biology·E J Luna
Jun 1, 1991·Experimental Cell Research·G CallainiM G Riparbelli
Feb 1, 1995·Differentiation; Research in Biological Diversity·V HuotariS Eskelinen
May 7, 2014·Methods : a Companion to Methods in Enzymology·Rafael S DemarcoD Leanne Jones
Dec 19, 2000·Mechanisms of Development·B Janzer, M Steinmann-Zwicky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.