Drosophila Syntrophins are involved in locomotion and regulation of synaptic morphology

Experimental Cell Research
Rika NagaiMasamitsu Yamaguchi

Abstract

Syntrophin components of the dystrophin glycoprotein complex (DGC) feature multiple protein interaction domains that may act in molecular scaffolding, recruiting signaling proteins to membranes and the DGC. Drosophila Syntrophin-1 (Syn1) and Syntrophin-2 (Syn2) are counterparts of human alpha1/beta1/beta2-syntrophins and gamma1/gamma2-syntrophins, respectively. alpha1/beta1/beta2-syntrophins are well documented, while little is known about gamma1/gamma2-syntrophins. Here, we performed immunohistochemical analyses with a specific antibody to Syn2 and demonstrated predominant expression in the larval and adult central nervous system. To investigate the in vivo functions of Syn2, we have generated Drosophila Syn2 deficiency mutants. Although the Syn2 mutants exhibit no overt phenotype, the combination of Syn1 knockdown and Syn2(37) mutation dramatically shortened life span, synergistically reduced locomotion ability and synergistically enhanced overgrowth of neuromuscular junctions in N-ethylmaleimide sensitive factor 2 mutants. From these data we conclude that Syn1 and Syn2 are required for locomotion and are involved in regulation of synaptic morphology. In addition, the two syntrophins can at least partially compensate for each...Continue Reading

References

Aug 1, 1994·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·B A StewartC F Wu
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·A H AhnL M Kunkel
Jul 14, 1997·The Journal of Cell Biology·M F PetersS C Froehner
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·L Misquitta, B M Paterson
Mar 29, 2000·Molecular and Cellular Neurosciences·N R Kramarcy, R Sealock
Apr 5, 2000·The Journal of Biological Chemistry·G PilusoV Nigro
Oct 6, 2000·FEBS Letters·M J Greener, R G Roberts
Apr 13, 2001·The Journal of Biological Chemistry·A P MayW I Weis
May 18, 2001·Developmental Biology·B A StewartG L Boulianne
Aug 2, 2002·Journal of Neurobiology·Bryan A StewartGabrielle L Boulianne
Mar 24, 2004·Journal of Structural Biology·Sidney W Whiteheart, Elena A Matveeva
May 27, 2004·Gene Expression Patterns : GEP·Linda C DekkersJasprina N Noordermeer
Nov 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marvin E AdamsStanley C Froehner
Apr 19, 2005·Genetics·Matthew J LavioletteBryan A Stewart
Dec 2, 2006·Genesis : the Journal of Genetics and Development·Jean-Baptiste PeyreBryan A Stewart
Jan 12, 2007·The EMBO Journal·Halyna R ShcherbataHannele Ruohola-Baker
Jan 19, 2007·Current Opinion in Neurobiology·Catherine A Collins, Aaron DiAntonio
Dec 29, 2007·Developmental Neurobiology·Sara Seabrooke, Bryan A Stewart
Oct 20, 2009·Experimental Cell Research·Rika NagaiMasamitsu Yamaguchi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Experimental Cell Research
Rika NagaiMasamitsu Yamaguchi
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Marvin E AdamsStanley C Froehner
Proceedings of the National Academy of Sciences of the United States of America
H M Sadoulet-PuccioL M Kunkel
© 2021 Meta ULC. All rights reserved