PMID: 2109192Apr 1, 1990Paper

Drosophila wing-spot test: improved detectability of genotoxicity of polycyclic aromatic hydrocarbons

Mutation Research
A Frölich, F E Würgler

Abstract

The somatic mutation and recombination tests (SMART) using eyes or wings in the fruit fly Drosophila melanogaster are flexible and sensitive systems for the detection of genotoxicity of individual chemical compounds and complex mixtures. It is of special interest that adults and larvae possess cytochrome P-450-dependent activation systems able to metabolize most promutagens, e.g., nitrosamines, aflatoxins, pyrrolizidine alkaloids, safrole, etc. The polycyclic aromatic hydrocarbons (PAHs) represent a class of promutagens poorly detectable in Drosophila genotoxicity systems. Therefore, new tester strains for the wing-spot test were constructed by introducing chromosomes 1 and 2 from a wild-type strain with increased cytochrome P-450-dependent metabolism linked to a gene on chromosome 2. Previous investigations with the new strains showed their increased detection capability for diethylnitrosamine. Comparative tests with the 3 PAHs benzo[a]pyrene, benz[a]anthracene and 7,12-dimethylbenz[a]anthracene demonstrate, in a reproducible way, that with the new strains all 3 can be detected as active genotoxic compounds. The dose-response curves for all compounds show a plateau with higher exposures. This is interpreted as indicative of a ...Continue Reading

References

Oct 1, 1977·Mutation Research·W G Blijleven, E Vogel
Apr 1, 1989·Mutation Research·U GrafF E Würgler
Jan 1, 1974·Molecular & General Genetics : MGG·A Garcia-Bellido, J Dapena
Jan 1, 1984·Environmental Mutagenesis·U GrafP G Kale
Mar 1, 1984·Chemico-biological Interactions·J A ZijlstraD D Breimer

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Citations

Dec 1, 1992·Mutation Research·E W Vogel
May 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·U GrafE Díaz Carrillo
Jan 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S K Abraham, U Graf
May 26, 1998·Environmental Health Perspectives·L Lagadic, T Caquet
Apr 29, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R R DihlH H R de Andrade
Jun 7, 2008·Environmental and Molecular Mutagenesis·Vânia Maria Sartini Dutra PimentaLuiz Alfredo Pavanin
May 4, 2005·Mutation Research·Viviane Souza do AmaralHeloisa Helena Rodrigues de Andrade
May 5, 2007·Environmental Pollution·Rafael Rodrigues DihlHeloísa Helena Rodrigues de Andrade
Jan 1, 1996·Environmental and Molecular Mutagenesis·C SanerC Sengstag
Feb 8, 2007·Environmental and Molecular Mutagenesis·Silmara de Moraes PantaleãoMário Antoônio Spanó
Feb 5, 2019·Toxicology Mechanisms and Methods·Okunola A AlabiYetunde M Adeoluwa
Jan 1, 1994·Environmental and Molecular Mutagenesis·M Batiste-AlentornR Marcos

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