Drosophotoxicology: An Emerging Research Area for Assessing Nanoparticles Interaction with Living Organisms

International Journal of Molecular Sciences
Mariana Carmen ChifiriucAlexandru Al Ecovoiu

Abstract

The rapid development of nanotechnology allowed the fabrication of a wide range of different nanomaterials, raising many questions about their safety and potential risks for the human health and environment. Most of the current nanotoxicology research is not standardized, hampering any comparison or reproducibility of the obtained results. Drosophotoxicology encompasses the plethora of methodological approaches addressing the use of Drosophila melanogaster as a choice organism in toxicology studies. Drosophila melanogaster model offers several important advantages, such as a relatively simple genome structure, short lifespan, low maintenance cost, readiness of experimental manipulation comparative to vertebrate models from both ethical and technical points of view, relevant gene homology with higher organisms, and ease of obtaining mutant phenotypes. The molecular pathways, as well as multiple behavioral and developmental parameters, can be evaluated using this model in lower, medium or high throughput type assays, allowing a systematic classification of the toxicity levels of different nanomaterials. The purpose of this paper is to review the current research on the applications of Drosophila melanogaster model for the in vivo...Continue Reading

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Jan 9, 2017·Journal of Hazardous Materials·Avnika Singh AnandEkta Kohli
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Methods Mentioned

BETA
transgenic
transfection

Software Mentioned

SMART

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