Drp1 is widely, yet heterogeneously, distributed in the mouse central nervous system.

Molecular Brain
Ting-Ting LuoYa-Yun Wang

Abstract

Drp1 is widely expressed in the mouse central nervous system and plays a role in inducing the mitochondrial fission process. Many diseases are associated with Drp1 and mitochondria. However, since the exact distribution of Drp1 has not been specifically observed, it is difficult to determine the impact of anti-Drp1 molecules on the human body. Clarifying the specific Drp1 distribution could be a good approach to targeted treatment or prognosis. We visualized the distribution of Drp1 in different brain regions and explicated the relationship between Drp1 and mitochondria. GAD67-GFP knock-in mice were utilized to detect the expression patterns of Drp1 in GABAergic neurons. We also further analyzed Drp1 expression in human malignant glioma tissue. Drp1 was widely but heterogeneously distributed in the central nervous system. Further observation indicated that Drp1 was highly and heterogeneously expressed in inhibitory neurons. Under transmission electron microscopy, the distribution of Drp1 was higher in dendrites than other areas in neurons, and only a small amount of Drp1 was localized in mitochondria. In human malignant glioma, the fluorescence intensity of Drp1 increased from grade I-III, while grade IV showed a declining tren...Continue Reading

References

Aug 22, 2001·Molecular Biology of the Cell·E SmirnovaA M van der Bliek
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Velia D'AgataSebastiano Cavallaro
Aug 2, 2003·Annals of Neurology·C Guin Ting WongO Carter Snead
Dec 23, 2003·The Journal of Comparative Neurology·Ralf K StummVolker Höllt
Jun 8, 2006·Annual Review of Biochemistry·Ronald J A Wanders, Hans R Waterham
Dec 8, 2006·Nature·Ed S LeinAllan R Jones
Dec 7, 2007·EMBO Reports·Chuang-Rung Chang, Craig Blackstone
Aug 2, 2008·Journal of Chemical Neuroanatomy·Ya-Yun WangYun-Qing Li
Dec 15, 2010·Brain Research Reviews·P Hemachandra ReddyPeizhong Mao
Apr 22, 2011·EMBO Reports·Catherine S PalmerMichael T Ryan
Aug 5, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luiz F FerrariJon D Levine
Sep 20, 2011·Nature·Marijn G J FordJodi Nunnari
May 24, 2012·Journal of Cell Science·William M Saxton, Peter J Hollenbeck
Feb 26, 2013·Biochimica Et Biophysica Acta·Hidenori OteraKatsuyoshi Mihara
Jul 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Lara GibelliniMarcello Pinti
Sep 15, 2015·Current Pharmaceutical Design·Maite SolasMaria J Ramirez
Jul 17, 2016·Journal of Bioenergetics and Biomembranes·Chun-Qiu DaiYa-Yun Wang
Jan 22, 2017·Experimental Gerontology·Aaron M GusdonCharleen T Chu
Apr 6, 2017·Antioxidants·Ju GaoXinglong Wang
Aug 18, 2017·Advances in Experimental Medicine and Biology·Mitsuo Tagaya, Kohei Arasaki
Dec 27, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Marco Antônio Peliky FontesFrédéric Frézard
May 29, 2018·Scientific Reports·Bernadeta Maria MichalskaJędrzej Szymański
Nov 27, 2018·Bioscience, Biotechnology, and Biochemistry·Unbin ChaeDong-Seok Lee
Apr 14, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kecheng ZhouSonghe Jiang
Sep 11, 2019·Nature Neuroscience·Caroline FecherThomas Misgeld

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
electron microscopy
confocal microscopy
PCR
acetylation
electrophoresis

Software Mentioned

ImageJ
Allen Mouse Brain Atlas
Image J

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.