Drug abuse and HIV-related pulmonary hypertension: double hit injury

AIDS
Zachery J HarterNavneet K Dhillon

Abstract

: Improved survival among HIV-1-infected individuals with the advent of antiretroviral therapy has clearly led to a greater prevalence of noninfectious complications. One of the most devastating sequelae in these individuals is the development of pulmonary arterial hypertension (PAH). Various epidemiological studies suggest worse survival of HIV-PAH patients when compared with other forms of PAH. Given that only a subset and not all HIV-infected individuals develop HIV-PAH, it is suggested that an additional second-hit of genetic or environmental trigger is needed for the development of PAH. In this context, it has been well documented that HIV patients who abuse illicit drugs such as stimulants, opioids, and the like, are more susceptible to develop PAH. In this review, we highlight the studies that support the significance of a double hit of HIV and drug abuse in the incidence of PAH and focus on the research that has been undertaken to unravel the pathobiology and vascular remodeling mechanisms underlying the deleterious synergy between HIV infection and drugs of abuse in orchestrating the development of PAH.

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Citations

Dec 8, 2019·Cardiovascular Drugs and Therapy·Michele CorrealeNatale Daniele Brunetti
Feb 29, 2020·Pulmonary Circulation·Stuti AgarwalNavneet K Dhillon
Apr 3, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stuti AgarwalNavneet K Dhillon
Jan 23, 2021·The Pediatric Infectious Disease Journal·Micah PiskeUNKNOWN CIHR Team Grant on Cellular Aging and HIV Comorbidities in Women and Children
May 21, 2021·American Journal of Respiratory Cell and Molecular Biology·Balaji KrishnamacharyNavneet K Dhillon

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