PMID: 2273461Sep 1, 1990Paper

Drug assay in ground tissues: example of ketoprofen diffusion into tonsillar tissue

Journal of Pharmaceutical Sciences
F LapicqueM Wayoff

Abstract

Ketoprofen was assayed in tissues of surgical patients after mechanical grinding of the tissue in liquid nitrogen; the fine powder obtained allowed the drug to be determined by HPLC in the same way as for liquid samples. The method was applied to the study of ketoprofen diffusion into the tonsillar tissue of 15 patients after a single intramuscular injection of ketoprofen (100 mg). A correction was made for blood contamination after hemoglobin determination.

References

Jul 1, 1987·Journal of Analytical Toxicology·G de Groot, K L Wubs
Jan 1, 1988·European Journal of Drug Metabolism and Pharmacokinetics·F Jamali
Apr 1, 1987·Journal of Pharmacokinetics and Biopharmaceutics·H MattieJ Hermans
Jul 1, 1987·Biopharmaceutics & Drug Disposition·L Y Shum, W J Jusko
Nov 1, 1987·Clinical Pharmacology and Therapeutics·P NetterR J Royer
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Jan 1, 1981·European Journal of Clinical Pharmacology·R A UptonS Riegelman

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Citations

Mar 1, 1991·Agents and Actions·B BannwarthA Gaucher
Oct 16, 2001·Journal of Pharmaceutical and Biomedical Analysis·F LagrangeB Bannwarth

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