Drug capture materials based on genomic DNA-functionalized magnetic nanoparticles

Nature Communications
Carl M BlumenfeldRobert H Grubbs

Abstract

Chemotherapy agents are notorious for producing severe side-effects. One approach to mitigating this off-target damage is to deliver the chemotherapy directly to a tumor via transarterial infusion, or similar procedures, and then sequestering any chemotherapeutic in the veins draining the target organ before it enters the systemic circulation. Materials capable of such drug capture are yet to be fully realized. Here, we report the covalent attachment of genomic DNA to iron-oxide nanoparticles. With these magnetic materials, we captured three common chemotherapy agents-doxorubicin, cisplatin, and epirubicin-from biological solutions. We achieved 98% capture of doxorubicin from human serum in 10 min. We further demonstrate that DNA-coated particles can rescue cultured cardiac myoblasts from lethal levels of doxorubicin. Finally, the in vivo efficacy of these materials was demonstrated in a porcine model. The efficacy of these materials demonstrates the viability of genomic DNA-coated materials as substrates for drug capture applications.

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Citations

Jan 7, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nikola Ž KneŽevićJean-Olivier Durand
Apr 13, 2021·Journal of Biomaterials Applications·Valerii B OrelValerii E Orel
Jun 15, 2021·ACS Applied Materials & Interfaces·Daryl W YeeJulia R Greer
May 30, 2019·ACS Central Science·Feng LiHai-Yan Xie
Nov 24, 2020·ACS Omega·Sankarganesh Krishnamoorthy, Robert H Grubbs
Oct 9, 2021·Signal Transduction and Targeted Therapy·Wenjuan MaYunfeng Lin

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Methods Mentioned

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electron
infrared spectroscopy
fluorescence microscopy
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