PMID: 9180131Jun 1, 1997Paper

Drug clearance and arterial uptake after local perivascular delivery to the rat carotid artery

Journal of the American College of Cardiology
M A LovichE R Edelman

Abstract

We attempted to characterize how drug released into the perivascular space enters the arterial wall and how it is cleared from the local environment. Drug released into the perivascular space can enter the artery either from the adventitial aspect or from the lumen after absorption by the extraarterial capillaries and mixing within the systemic circulation. Some investigators suggest that this latter mechanism dominates, and they question whether local drug release is synonymous with local deposition. We investigated both the pathways by which adventitially released drug is cleared from the perivascular space and those by which drug enters the blood vessel wall. Inulin was used to follow drug release from implanted devices and subsequent entry to the circulation, because of its first-pass urinary excretion. Heparin was used to follow arterial deposition because of its vasoactivity and tissue-binding properties. The different potential pathways of drug entry and egress were systematically removed and the effects on metabolism and deposition determined. Ligature occlusion of the artery did not decrease inulin excretion or heparin deposition. Extravascular wraps designed to shield the device from extramural capillaries reduced inu...Continue Reading

References

May 1, 1978·Thrombosis Research·B GlimeliusM Höök
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E R EdelmanM J Karnovsky
Jul 1, 1990·Archives of Otolaryngology--head & Neck Surgery·N S JonesM R Mayberg
May 30, 1985·Biochimica Et Biophysica Acta·T BârzuJ Caen
Jul 1, 1985·Journal of Cellular Physiology·J J CastellotM J Karnovsky
Oct 1, 1983·Journal of Pharmaceutical Sciences·L R BrownR Langer
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·A NathanE R Edelman
Feb 1, 1995·Circulation Research·E R EdelmanR D Rosenberg
Sep 1, 1994·Journal of the American College of Cardiology·H Wolinsky
Apr 1, 1994·Journal of the American College of Cardiology·R Riessen, J M Isner
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E R EdelmanM J Karnovsky

❮ Previous
Next ❯

Citations

Aug 22, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·A W Heldman, J A Brinker
Mar 23, 2006·Pharmaceutical Research·Kosalaram GotetiSteven E Kern
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y An, J A Hubbell
Mar 6, 1998·Nature Biotechnology·E R Edelman, M Lovich
Jun 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew D LevinElazer R Edelman
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·M A Lovich, E R Edelman
Nov 21, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Abraham R TzafririElazer R Edelman
Jan 24, 2015·European Journal of Clinical Investigation·Vivian G NgAlexandra J Lansky
Apr 18, 2006·Advanced Drug Delivery Reviews·Chiming Yang, Helen M Burt
Jul 27, 2001·The Journal of Surgical Research·H M Nugent, E R Edelman
May 18, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mirnal A ChaudharyK Craig Kent
May 29, 1999·Annals of Vascular Surgery·Y G WolfS Banai
Dec 18, 2001·Journal of Pharmaceutical Sciences·M A LovichE R Edelman
Apr 29, 2000·Circulation Research·C J CreelE R Edelman
Mar 11, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·I FishbeinG Golomb
Dec 9, 1998·The American Journal of Physiology·M A LovichE R Edelman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.