Drug-Coated Balloon for De Novo Coronary Artery Disease: JACC State-of-the-Art Review

Journal of the American College of Cardiology
Charan YerasiRon Waksman

Abstract

Percutaneous coronary intervention with a drug-eluting stent is the most common mode of revascularization for coronary artery disease. However, restenosis rates remain high. Non-stent-based local drug delivery by a drug-coated balloon (DCB) has been investigated, as it leaves no metallic mesh. A DCB consists of a semicompliant balloon coated with antiproliferative agents encapsulated in a polymer matrix, which is released into the wall after inflation and contact with the intima. DCB have demonstrated effectiveness in treating in-stent restenosis. Clinical studies using DCB in de novo coronary artery disease have shown mixed results, with a major benefit in small-vessel disease. Differences in study results are not only due to variations in DCB technology but also to disparity in procedural approach, "leave nothing behind" or "combination therapy," and vessel size. This review focuses on the available evidence from randomized trials and proposes a design for future clinical trials.

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Citations

Jul 17, 2020·Expert Review of Cardiovascular Therapy·Valentina CaponeCiro Santoro
Sep 15, 2020·Internal Medicine·Yukiko MizutaniIsao Taguchi
Jan 26, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Hak Seung LeeHyo-Soo Kim
Nov 3, 2020·Journal of Interventional Cardiology·Gianluca CaiazzoLuciano Fattore
Apr 24, 2021·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Bernardo CorteseSalvatore De Rosa
Jun 6, 2020·JACC. Cardiovascular Interventions·Chava Chezar-AzerradRon Waksman
Jun 3, 2021·Materials·Alexandru Scafa UdrișteElisabeta Bădilă
Jun 7, 2021·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Kazuhiro DanHector M Garcia-Garcia
Jul 28, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Liang PanChunguang Qiu

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