Drug concentrations in the serum and cerebrospinal fluid of patients treated with cefoperazone/sulbactam after craniotomy

BMC Anesthesiology
Qiang WangJianxin Zhou

Abstract

To identify changes in cefoperazone/sulbactam penetration into cerebrospinal fluid (CSF) after craniotomy and to investigate preliminarily whether cefoperazone/sulbactam CSF concentration can reach therapeutic level when administered intravenously after neurosurgical operation. Neurosurgical patients with an indwelling ventricular drainage pipe who received prophylactic cefoperazone/sulbactam for the treatment of intracranial infection were received a cefoperazone/sulbactam 2:1, 3.0-g infusion for 3 hours every 6 hours for 24 h. Venous blood and CSF specimens were collected to determine cefoperazone/sulbactam concentrations. The cefoperazone and sulbactam concentrations in serum were highest at the second hour (237.54 ± 336.72 mg/L and 66.52 ± 80.38 mg/L, respectively) and then decreased. The cefoperazone and sulbactam concentrations in CSF were highest at the 4th hour (39.22 ± 75.55 mg/L and 6.24 ± 8.35 mg/L, respectively) and then decreased. CSF penetration measured by the ratio of peak concentrations (CSF/serum) was 8.6% ± 7.2% for cefoperazone and 13.5% ± 11.9% for sulbactam, CSF penetration measured by the ratio of trough concentrations (CSF/serum) was 13.4% ± 5.3% for cefoperazone and 106.5% ± 87.5% for sulbactam. CSF pen...Continue Reading

References

Nov 1, 1990·The Journal of Antimicrobial Chemotherapy·Y Obana, T Nishino
Oct 1, 1994·Antimicrobial Agents and Chemotherapy·B G KuahH R Chang
May 16, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A S Levin
May 4, 2004·International Journal of Antimicrobial Agents·Ana Isabel Dueñas DíezAntonio Rodríguez-Torres
Jan 6, 2010·International Journal of Antimicrobial Agents·Hui WangXinhong Huang
May 14, 2010·The New England Journal of Medicine·Anton Y Peleg, David C Hooper

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Citations

Oct 16, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y WuQ Wang
Mar 5, 2020·The Journal of Antimicrobial Chemotherapy·Hai-Yan ShiWei Zhao
Jun 25, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yan TanChuanpin Chen
Sep 25, 2018·Critical Care : the Official Journal of the Critical Care Forum·Rui Pedro Veiga, José-Artur Paiva
Jan 9, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yee-Huang Ku, Wen-Liang Yu

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