PMID: 20629324Jul 16, 2010Paper

Drug delivery of CPC/amifostine/cisplatin complex in vitro and its ability in repairing bone defect and eliminating tumor in vivo

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Yan-ning LiuPeng-yu Ren

Abstract

To investigate the feasibility of using calcium phosphate cement/amifostine/cisplatin complex to fill and repair bone defect, caused by tumor resection. Drug concentration in the CPC/ amifostine/cisplatin complex was determined. Rabbits with bone defect and rats with osteosarcoma were implanted with CPC and CPC/amifostine/cisplatin complex. Similar bone growth was observed in the femurs of rabbits implanted with CPC/amifostine/cisplatin complex and those implanted with CPC. CPC/amifostine/cisplatin complex delivered amifostine and cisplatin consistently and eliminated osteosarcoma cells implanted in the rats. CPC/amifostine/cisplatin complex repairs bone defect caused by tumors as a filling material.

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